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  • Cardiac Systems Pharmacology Group

    Led by Jeffrey Saucerman,PhD, the CSPG combines computational modeling and experiments to discover molecular networks that control cardiac remodeling and regeneration.

Our Research

Heart function and failure are controlled by complex molecular networks that are just beginning to be mapped. The CSPG combines computational modeling and experiments to discover molecular networks that control cardiac remodeling and regeneration.

Specific research focus areas include cardiomyocyte hypertrophy and death, extra-cellular matrix remodeling by fibroblasts and macrophages, and cardiomyocyte proliferation.

Latest News

Selected Publications

  • Matrix Biology ABS Computational model predicts paracrine and intracellular drivers of fibroblast phenotype after myocardial infarction
  • Frontiers in Physiology ABS Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling
  • Nature Reviews Cardiology ABS Mechanical regulation of gene expression in cardiac myocytes and fibroblasts
  • Journal of Molecular and Cellular Cardiology ABS High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets

More About Us

People

We are based in the Department of Biomedical Engineering at the University of Virginia. Our group is a diverse mixture of graduate students, undergraduate students, post-docs and research specialists.

Group Members and Contact

Research

We are discovering the molecular networks that control cardiac remodeling, through a combination of systems modeling and experiments.

Current Projects

News

Twitter is the place to find the latest news about the CSPG. More detailed discussions can be found on our blog.

Saucerman Lab on Twitter
Automated image analysis of cardiac cells and tissue

Automated image analysis of cardiac cells and tissue.