Biomedical circuits and signal analysis systems for measurement within microsystems
Abstract: Microsystems are commonly applied to study biological tissues, cells, microbials, and molecules, due to their capability for enabling microfluidic separation towards selective enrichment, high levels of parallelization and highly sensitive measurements. However, current innovations to enhance measurements of biomedical significance are chiefly focused on the sphere of materials chemistry and device design. This dissertation is focused on the design and development of electronic circuits and signal analysis systems to enhance the ability for: (i) high-power and bandwidth electrical stimulation for frequency-selective microfluidic manipulation of Biosystems, (ii) Circuit for quantifying the level and frequency response of electrical field penetration to optimize particle manipulation in microfluidic devices. (iii) high-sensitivity surface electromyography (sEMG) measurements over a background of electrical stimulation, and (iv) Portable multi-channel HV power supply and real-time impedance analysis systems for sample manipulation by electrophoresis and acoustophoresis within resource-poor settings.