Understanding Crystallization Fundamentals
1. MOF Morphology Control
Chemical modulation can have an impact on MOF properties, including BET surface area, faceting, and the primary exposed pore for anisotropic MOFs.
In two systems (Zinc based BDC DABO and Zirconia based UIO-66) we have demonstrated tunable crystal shape and faceting. When pores shape is anisotropic, this can have relevance for separations and storage by controlling the timescales of diffusion throughout the framework.
2. MOF Solution Processing
This project is focused on the fabrication and control of thin film Metal Organic Frameworks (MOFs). We are exploring the fundamentals of MOF crystallization as well as control of particle deposition to fabricate thin films from a wide range of MOFs. These films can then be used for applications ranging from gas separation to desalination and sensing. By exploring these techniques we hope to better understand the relationship between MOF crystallization, film quality and fabrication technique.
Using solution shearing and modulation, oriented thin films of metal organic frameworks can be created.
3. Polymorphism in Pharmaceutical Compounds
In drug delvelopment, it is important to identify polymorphism as it can occur during crystallization. Unwanted polymorphs can lead to changes in drug performance. As such, the most stable form is often selected for development, but through using different processing techniques (like solution shearing) we can stabilize other metastable forms, which have enhanced kinetics associated with drug delivery and response time.