News briefs for the Hossack Lab

    New Coulter Award

    October 17, 2022

    Hossack lab has a new Coulter Partnership Award of $136,00 for the design of a therapeutic ultrasound approach for the treatment of degenerative heart valve disease. The Principal Investigators are: John A. Hossack, Biomedical Engineering and Patricia Rodriguez Lozano, M.D., Cardiovascular Medicine. Clinical Co-Investigators include: Austin Robinson, M.D., Mohamed Morsy, M.D., and Christopher Kramer M.D., Cardiovascular Medicine and Radiology. New designs will be developed using Finite Element Analysis to evaluate technical tradeoffs. The project will involve simulation and in vitro testing. Some ex vivo testing will be performed subject to availability of suitable tissue.

    Elizabeth Wins International Poster Award

    January 29, 2021

    "Enhanced visualization of ultrasound contrast agents using normalized singular spectrum area and singular value thresholding"

    Elizabeth Herbst has won a poster award at the annual European Symposium on Ultrasound Contrast Imaging, a top level inernational meeting in the field of ultrasound contrast. Her presentation for was chosen among a group of 16 presenters in ultrasound contrast imaging. Co-authors on the work include Dr. John Hossack, Dr. F. William Mauldin, and Dr. Alexander Klibanov.

    Elizabeth’s project in ultrasound molecular imaging utilizes singular value decomposition-based signal processing techniques to automatically segment and identify ultrasound contrast agent signals based on their unique spatiotemporal signatures. This innovative filtering technique has the potential to improve the visualization of cancer and other vascular diseases in future clinical settings.

    Movie showing filtering Technique (.avi)

    Microbubbles, Microfluidics, and Molecular Localization: Our Latest Publications

    October 12, 2020

    Congrats to Yanjun, Feifei and Elizabeth authors of the lab's four most recent publications:

    • Yanjun Xie for "Real-time control of microbubble diameter from a flow-focusing microfluidic device" (a conference paper in IEEE International Ultrasonics Symposium).
    • Yanjun Xie for "Closed-loop feedback control of microbubble diameter from a flow-focusing microfluidic device" (Journal paper in Biomicrofluidics).
    • Feifei Zhao for "A Targeted Molecular Localization Imaging Method Applied to Tumor Microvasculature" (a journal paper in Investigative Radiology). 
    • Elizabeth Herbst for "Enhanced visualization of intratumoral microbubbles using singular value thresholding combined with normalized singular spectrum area" (Conference paper in IEEE IUS).

    Improving Prostate Cancer Diagnosis: New Coulter Award

    October 12, 2020

    Hossack Lab has been awarded $97K from the UVA-Coulter Partnership for "Super resolution molecular imaging for improved prostate cancer diagnostic performance."  Our proposal addresses new methods of ultrasound parameter setting and signal processing to yield approximately five fold improvement in resolution for ultrasound imaging combined with imaging of molecular signature of cancer.


    Elizabeth Earns Fellowship from the American Heart Association

    January 07, 2020

    Elizabeth Herbst has won an American Heart Association Pre-Doctoral Fellowship! Her project focuses on the use of ultrasound molecular imaging to characterize the aneurysmal abdominal aorta.

    Hossack Lab at IEEE in Scotland

    October 21, 2019

    Hossack Lab grad students Elizabeth Herbst and Yanjun Xie presented their research at the 2019 IEEE International Ultrasonics Symposium in Glasgow, Scotland. Yanjun's research focused on designing a feedback control system on the diameters of microbubbles produced by a flow-focusing microfluidic device. Elizabeth's research was focused on the use of normalized singular spectrum area to isolate unique signals from ultrasound contrast agents.