Identification of Disease Biomarkers

Proteomic strategies that allow unbiased identification of proteins and their post-transcriptional and -translational modifications are an essential complement to genomic strategies. We have developed a method to couple the power of combinatorial screening technologies such as phage display to identify those ligands.

Select Publications 

  • Gutknecht MF, Seaman ME, Ning B, Cornejo DA, Mugler E, Antkowiak PF, Moskaluk CA, Hu S, Epstein FH, Kelly KA. Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity. Nature communications. 2017 Sep 15;8(1):552.
  • Brinton LT, Bauknight DK, Dasa SS, Kelly KA. PHASTpep: analysis software for discovery of cell-selective peptides via phage display and next-generation sequencing. PloS one. 2016 May 17;11(5):e0155244.
  • Bausch, D, Thomas, S, Mino-Kenudson, M, Fernandez-del Castillo, Bauer, TW, Williams, M, Warshaw, AL, Thayer, SP, and Kelly, KA.  Plectin-1 as a novel biomarker for pancreatic cancer.  Clinical Cancer Research, 2010 Nov 23   PMCID: PMC3044444