Previously Funded Coulter Projects


UVA-Coulter builds networks of relationships around our researchers, connecting them with veteran entrepreneurs, investors and experts in such fields as clinical trials, regulation, and patents and licensing. Because every new technology has its own requirements and follows its own path to the marketplace, we approach each project differently. The exchange of ideas, insight and information is the engine that moves innovative technologies from university laboratories to the marketplace. We now have twelve years’ experience taking biomedical innovations born in the academic environment and translating them into practical use.

Projects Funded for 2019-2020

  • Recombinant Immunogen Bacterial Vaccines

    Mark Kester, Ph.D. (Pharm/BME) and Steven Zeichner, M.D., Ph.D. (Pediatrics)


    Safe and effective vaccines for important pathogens exist, but there still no safe and effective vaccines for many other important pathogens. Among important diseases that lack effective vaccines are those caused by enveloped viruses, e.g. HIV and influenza. Neutralizing antibodies made against enveloped viruses typically target viral envelope proteins present on the virion envelope surface in the context of the envelope’s lipid bilayer. This project will combine novel immunogen presentation with synthetic biology to create a platform to develop new vaccines. 

  • Big Data Science at the Bedside

    Randall Moorman, M.D. (Cardiology), Karen Fairchild, M.D. (Pediatrics) and Tim Clark, Ph.D. (Data Science)


    The project centers on advanced analysis of Big Data captured from continuous cardiorespiratory monitoring, here in the special case of premature infants. The UVa Center for Advanced Medical Analytics has a unique opportunity to advance the field of predictive analytics monitoring through a new approach of highly comparative time series analysis, using the largest database of clinical and cardiorespiratory monitoring data extant, generated by 2 ongoing NIH multicenter grants. This will result in new families of algorithms for early detection of subacute potentially catastrophic illnesses.

  • Improved Electrocardiograms for Cardiac MRI

    Craig H. Meyer, Ph.D. (BME and Radiology) and Chris Kramer, MD (Cardiology and Radiology)


    Cardiac MR (CMR) provides a wealth of information, including images of cardiac anatomy and function, myocardial perfusion, and myocardial scarring after myocardial infarction. Central to CMR is the synchronization the acquisition of data to the heart cycle, so that the reconstructed images correspond to a particular time in the heart cycle. CMR data acquisition is typically synchronized to the heart cycle using an electrocardiogram (ECG). Acquiring an accurate ECG within the MRI scanner is difficult, and the most difficult problem is the presence of artifacts in the ECG. The overall goal of this project is to develop and validate a deep-learning-based method for correcting the ECG signal within a 3T MRI scanner, resulting in more reliable cardiac MRI.

  • Laryngeal reconstruction using microporous annealed particle hydrogel

    Donald Griffin (BME) and James Daniero (Head and Neck Surgery)


    Validation of new injectible filler for the treatment of glottic incompetence and comparison of outcomes to the current standard. 

  • Low Field Cardiac and Lung MRI

    Craig Meyer, Ph.D. (BME and Radiology) and Michael Salerno M.D., Ph.D.(Cardiovascular Medicine/BME)


    This project focuses on determining whether it is possible to achieve better imaging for certain diagnostic tasks at a much lower field strength by combining modern high-end MRI scanner hardware with leading-edge MRI techniques. If it is possible, this could lead to manufacturers producing a new type of low field MRI scanner at lower cost, with greater compatibility with implantable devices, and with new diagnostic capabilities.  If successful, we plan to commercialize the technology first through a partnership with an MRI scanner manufacturer and then through licensing to other manufacturers.

Projects Funded for 2018-2019

  • ERK-dependent suicide gene therapy for glioblastoma multiforme

    Matthew Lazzara (CHE/BME) and Benjamin Purow (Neurology)


    Here, we propose to take thenext steps toward clinical translation of our new suicide gene approach by: 1) Demonstrating and tuning its selective ability for cell killing across different cell types present in GBM tumors, and 2) Determining its utility as an effective therapy in mouse models of GBM.

  • Brain Attack and Neurological Deficit Identification Tool (BANDIT)

    Gustavo Rodhe (BME) and Andrew Southerland (Neurology)


    The goal of this project is to develop a quantitative screening tool for more accurate diagnosis and triage of stroke and LVO patients and implement it on a real time system capable of providing clinically relevant information for cases when expert neurologists are not immediately available.

  • Novel biosensor for clinical assessment of plantar-surface diabetic foot ulcers

    Shayn Peirce Cottler (BME), Cassandra Fraser (Chemistry), Catherine Ratliff (Plastic Surgery), Chris Campbell (Plastic Surgery), Patrick Cottler (Plastic Surgery)


    First-in-man safety study of a novel biopolymer-based biosensor to assess the healing potential of diabetic foot ulcers, while expanding clinical utility to include evaluating the extremities of peripheral arterial disease patients.

  • Laryngeal reconstruction using microporous annealed particle hydrogel

    Donald Griffin (BME) and James Daniero (Head and Neck Surgery)


    Validation of new injectible filler for the treatment of glottic incompetence and comparison of outcomes to the current standard. 

  • Development of a pulse sequence for rapid free-breathing and non-ECG gated CMR evaluation of heart failure

    Michael Salerno (Cardiovascular Medicine/BME), John Mugler (Radiology/BME), and Dan Weller (ECE)


    The goal is to extend and validate our spiral Siemens product framework by developing a technique to simultaneously obtain cine and T1 mapping (or LGE) images with whole heart coverage.

  • Accelerated cine DENSE strain MRI using a novel simultaneous multislice method

    Fred Epstein (BME) and Ken Bilchick (Cardiovascular Medicine)


    Development and evaluation of a novel simultaneous multislice (SMS) method for spiral cine DENSE to facilitate greater usage of strain imaging as a routine component of a rapid, efficient multiparametric cardiac MRI protocol.

  • Magnetogenetic approach to treat nervous system dysfunction

    Christopher Deppmann (Biology/BME), Ali Guler (Biology), and Nicole Deal (Orthopaedic Surgery)


    Optimizing the expression of magnetically gated actuators to make these tools as robust as possible, enuring that companies and academic labs may use them with ease, while also considering side effects and potential toxicity associated with their use.

Projects Funded for 2017-2018

  • Development of a 12-minute free-breathing cardiac MRI protocol for the evaluation of heart failure

    John Mugler (Radiology/BME) and Michael Salerno (Cardiovascular Medicine/BME)


    Developing a rapid free-breathing cine and LGE techniques based on UVA spiral pulse sequence technology to perform a comprehensive assessment of myocardial function and scar in heart failure in less than 15 minutes.

  • Designing antibiotics for bacterial uptake

    Peter Kasson (Molecular Physiology/BME) and Robert Striker (Infectious Diseases, U. Wisconsin-Madison)


    Developing a generalizable process to determine chemical features that determine whether a drug will reach its target in gram-negative bacteria and incorporate this into the lead optimization process--leading to an enabling technology that will have broad utility in antibiotic development.

  • Laryngeal Reconstruction using microporous annealed particle hydrogel

    Donald Griffin (BME) and James Daniero (Otolaryngology-Head and Neck Surgery)


    The proposed work will likely reach a series of IP-generating milestones, including: 1) the first injectable scaffold that avoids both resorption and immunogenicity, 2) a novel material strategy for accelerated tissue integration, and 3) a treatment that restores clinical loss of vocal fold function due to glottic incompetence.

  • Novel biosensor for clinical assessment of plantar-surface diabetic foot ulcers

    Shayn Peirce Cottler (BME), Cassandra Fraser (Chemistry), Catherine Ratliff (Plastic Surgery), Chris Campbell (Plastic Surgery), Patrick Cottler (Plastic Surgery)


    UVA-owned technology has the potential to transform how plantar-surface diabetic ulcers are managed by providing a more direct and accurate assessment of healing potential, which will lead to more informed clinical decision making about the course of treatment for these difficult-to-manage wounds.

  • Real time ultrasound guidance for breast cancer margin oncology procedures

    John Hossack (BME), Timothy Showalter (Radiation Oncology) and David Brenin (Breast Surgery)


    Year 2 continuation, focused on device validation and improvement, with emphasis on patient studies, workflow, and technical improvements to address optimal workflow/efficacy.

  • A deep learning MRI framework for quantitative assessment of hypertrophic cardiomyopathy

    Craig Meyer (BME) and Chris Kramer (Cardiovascular Medicine)


    The goal of this study is to greatly improve the efficiency and robustness of quantitative cardiac magnetic resonance markers of hypertrophic cardiomyopathy (HCM). These markers will initially be applied to the characterization of the important clinical problem of HCM, but the methods will be applicable to other cardiac diseases.

  • Verification and validation of a device for reducing the transmission of pathogens from hospital sink wastewater to patients

    William S. Guilford (BME), Amy Mathers (Infectious Disease), Shireen Kotay (Infectious Disease)


    Gather end-user feedback of the generation 2 device by deploying a “sink in a box” at three hospitals and redesign device using end-user feedback. Test to define the operational parameters in the UVA Sink Lab and submit for UL-certification.   

Projects Funded for 2016-2017

  • Feeding device for infants with cleft palate and other feeding disorders

    Silvia Blemker (BME) & Kathleen Borowitz (Pediatrics)


    The new design enables the infant to make more efficient use of the tongue in order to extract milk from the bottle, and it has different flow control inserts to all for variable flow rates that accommodate infants as they grow.

  • High resolution whole heart CMR perfusion imaging for improved diagnosis of coronary heart disease

    John Mugler (Radiology/BME) and Mike Salerno (Cardiovascular Medicine/BME)


    New spiral perfusion technique developed at UVA to achieve whole heart coverage with a spatial resolution of <1.5 mm.

  • Real-time ultrasound guidance for breast cancer margin oncology procedures

    John Hossack (BME), Timothy Showalter (Radiation Oncology) and David Brenin (Breast Surgery)


    Adapting the balloon applicator used in breast oncology to include a rotationally scanning small-scale ultrasound imaging catheter to perform intraoperative radiation therapy (IORT) with real-time image guidance without the cost, complexity and radiation of CT.

  • Optimized predictive monitoring of non-ICU patients at risk for sepsis

    Laura Barnes (SIE) and Christopher Moore (Infectious Diseases)


    Overcomes the limitations of existing systems such as the SIRS criteria and a new clinical sepsis definition by developing a new computational framework for the prediction of sepsis using commonly available indicators and predicts the individual response to treatment after diagnosis.

  • Tissue Engineered Muscle Repair (TEMR) for treatment of Volumetric Muscle Loss (VML) of the hand

    George Christ (BME/Orthopaedic Surgery) and A. Bobby Chhabra (Orthopaedic Surgery)


    In order to further extend the clinical applications of our TEMR technology platform we propose to continue development of our second generation TEMR construct for applications to volumetric muscle loss injuries to intrinsic muscles of the hand.

  • Magnetogenetic approach for the treatment of nervous system injury

    Chris Deppmann (Biology/BME), Ali Guler (Biology) and Nicole Deal (Orthopaedic Surgery)


    Tests whether a novel remote nerve cell stimulation paradigm can promote regeneration in pre-clinical rodent models for nerve injury with the goal of moving magnetogenetic actuators into human trials for nervous system injury.

  • Lipid nanoparticle-based fluorescence detection technology for a new generation of high-sensitivity immunoassays

    Alexander Klibanov (Medicine/BME), Ayotunde Dokun (Endocrinology), Bruce Gaylinn (Endocrinology), and Leon Farhi (Endocrinology)


    Novel nanoparticle detection technology to ptovide a general solution to many assays in need of better performance, leading to a new generation of clinically important high sensitivity immunoassays with improved range, stability, simplicity and reproducibility.

  • Superbug Tracker

    Jason Papin (BME), Laura Barnes (SIE), Don Brown (CS), Jennifer Lobo (Public Health), Amy Mathers (Infectious Disease)


    Design of a context-aware surveillance systems for nosocomial outbreaks involving non-patient resevoirs.