Advancing Cardiac Magnetic Resonance Imaging
Cardiovascular magnetic resonance imaging (CMR), also known as cardiac MRI, is a medical imaging technology for non-invasive assessment of the function and structure of the cardiovascular system. The development of CMR is an active field of research and continues to see a rapid expansion of new and emerging techniques.
Spiral perfusion imaging
First-pass contrast-enhanced myocardial perfusion MRI has proven to be a promising noninvasive technique for evaluating patients with known or suspected coronary artery disease (CAD), demonstrating excellent diagnostic and prognostic utility.
Our lab aims to develop fast and high-resolution spiral quantitative perfusion imaging techniques with whole-heart coverage. Specifically, we have demonstrated good performances utilizing variable density spiral trajectories, parallel imaging, compressed sensing, outer volume suppression and simultaneous multi-slice techniques.
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Yang, Y., Kramer, C.M., Shaw, P.W., Meyer, C.H. and Salerno, M. (2016), First‐pass myocardial perfusion imaging with whole‐heart coverage using L1‐SPIRiT accelerated variable density spiral trajectories. Magn. Reson. Med., 76: 1375-1387. doi:10.1002/mrm.26014
Yang, Y., Zhao, L., Chen, X., Shaw, P.W., Gonzalez, J.A., Epstein, F.H., Meyer, C.H., Kramer, C.M. and Salerno, M. (2018), Reduced field of view single‐shot spiral perfusion imaging. Magn. Reson. Med., 79: 208-216. doi:10.1002/mrm.26664
Yang, Y, Meyer, CH, Epstein, FH, Kramer, CM, Salerno, M. Whole‐heart spiral simultaneous multi‐slice first‐pass myocardial perfusion imaging. Magn Reson Med. 2019; 81: 852– 862. https://doi.org/10.1002/mrm.27412
Respiratory-induced motion artifacts correction for k-t accelerated and compressed-sensing CMR perfusion imaging
We proposed a simple respiratory motion compensation strategy for k-t accelerated and compressed-sensing CMR perfusion imaging to selectively correct respiratory motion of the heart, based on linear k-space phase shifts derived from rigid motion registration of a heart region of interest. The results of phantom and human subjects can be visualized in Figure 1 and Figure 2.
Free Breathing Cine Imaging with Motion-Corrected Reconstruction at 3T Using SPiral Acquisition with Respiratory correction and Cardiac Self-gating
Cine data were acquired continuously on a 3T scanner for 8 seconds per slice without ECG gating or breath-holding, using a golden-angle gradient echo spiral pulse sequence. Cardiac motion information was extracted by applying principal component analysis on the gridded 8×8 k-space center data. Based on the previous study, respiratory motion was corrected by rigid registration on each heartbeat. With an 8-second data acquisition per slice, whole heart cine images with clinically acceptable spatial and temporal resolution and image quality can be acquired in less than 90 seconds of free-breathing acquisition. Movie 1 showed an example of SPARCS whole-heart coverage subject results.
Movie 1 2.mp4
Cine And T1 mapping SPiral Acquisition with Respiratory and Cardiac Self-gating (On-going project)
Based on the SPARCS technique, we proposed to simultaneously perform cine, T1 mapping, and LGE (post contrast) in a single acquisition with whole heart coverage in under 5 minutes.