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Tools and paradigms for non-invasive precision cancer management

The Sheybani Lab at the University of Virginia is working at the nexus of therapeutic ultrasound, advanced imaging, and tumor immunology to design and deploy precision cancer immunotherapy paradigms. The group seeks to advance the role of focused ultrasound (FUS) for immuno-modulation and immunotherapy delivery in solid cancers of the brain and periphery.

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Selected Publications

  • Profiling of the Tumor-Immune Landscape in Murine Glioblastoma following Blood Brain/Tumor Barrier Disruption with MR Image-guided Focused UltrasoundABS Journal of Neuro-Oncology (Special Issue: Focused Ultrasound in Neuro-Oncology) (2021). Sheybani ND, Witter AR, Garrison WJ, Miller GW, Bullock TNJ, Price, RJ
  • Functional Intersections Between Extracellular Vesicles and Oncolytic TherapiesABS Trends in Pharmacological Sciences (2021).Clark RA, Garman ZG, Price RJ, Sheybani ND
  • ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls gliomaABS Journal of Controlled Release (2021). Sheybani ND, Breza VR, Paul S, McCauley KS, Berr SS, Miller GW, Neumann KD, Price RJ
  • Combination of Thermally Ablative Focused Ultrasound with Gemcitabine Controls Breast Cancer via Adaptive ImmunityABS Journal for ImmunoTherapy of Cancer (2020). Sheybani ND*, Witter AR*, Thim EA, Yagita H, Bullock TNJ, Price RJ
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Focused Ultrasound Cancer Immunotherapy Center at the University of Virginia

Our mission is to differentiate UVA as the worldwide leader in translational FUS immuno-oncology research.

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Sheybani Lab 2022.