Previous Virginia iGEM Teams
Previous awarding-winning iGEM teams have tackled problems improving the environment, understanding the metabolics of synthetic biology, disease, genetics, and many others! Click to explore different years' accomplishments.
Manifold Phase I: Proteinous Shells with Encapsulated DNA Scaffolds for Improving the Capability and Efficiency of Biosynthesis
The lack of a versatile and reliable way to improve metabolic flux channeling, pathway orthogonality, and product yields is a major impediment to the expanded utilization of biosynthesis for the production of drugs and industrially valuable chemicals. Manifold, a platform technology that addresses this problem, consists of bacterial microcompartments (BMCs) with encapsulated dsDNA scaffold that sequester and spatially organize, at fixed concentrations, biosynthetic enzymes presented as zinc-finger fusion proteins. Here we deliver the designs for an E. coli cell capable of synthesizing resveratrol using the Manifold platform. The Manifold platform will help lower costs and expand the applications of chemical biosynthesis.
Team members: Jacob Polzin, Veronica Gutierrez, Dev Patel, Aparna Kola, Apekchha Pradhan, Colin Haws, Julia Ball, Collin Marino, Pietro Revelli, Sophia Link, and Eddie Micklovic