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Microsystems for precision medicine

Biological function and disease progression are often linked to the emergence of phenotypic heterogeneity, wherein fractional subpopulations determine the net response of biosystems. Using novel configurations of biomedical devices, circuits and signal analysis systems, our group is focused on microfluidic biofabrication, sensing and separation platforms for label-free biophysical stratification of the emerging heterogeneity with single-cell sensitivity. Our strength is in measurement of label-free metrics based on subcellular electrophysiology, deformability and biomarker secretions, which are often integrated with on-chip sensing, signal analysis and actuation approaches. Based on this, we seek to uncover precision medicine-based approaches for disease diagnostics, biomanufacturing and to screen subjects for regenerative therapies.