By turning off a single gene, University of Virginia researchers and their collaborators caused stem cells already becoming heart...
Heart function and failure are controlled by complex molecular networks that are just beginning to be mapped. The CSBG combines computational modeling and experiments to discover molecular networks that control cardiac remodeling and regeneration.
Specific research focus areas include cardiomyocyte hypertrophy and death, extra-cellular matrix remodeling by fibroblasts and macrophages, and cardiomyocyte proliferation.
- CPT Pharmacometrics Syst Pharmacol ABS Network model-based screen for FDA-approved drugs affecting cardiac fibrosis
- J Immunol ABS Network Analysis Reveals a Distinct Axis of Macrophage Activation in Response to Conflicting Inflammatory Cues
- Nat Rev Cardiol ABS Mechanical regulation of gene expression in cardiac myocytes and fibroblasts
- Journal of Molecular and Cellular Cardiology ABS High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
More About Us
We are based in the Department of Biomedical Engineering at the University of Virginia. Our group is a diverse mixture of graduate students, undergraduate students, post-docs and research specialists.Group Members and Contact
We are discovering the molecular networks that control cardiac remodeling, through a combination of systems modeling and experiments.Current Projects
Twitter is the place to find the latest news about the CSBG. More detailed discussions can be found on our blog.Saucerman Lab on Twitter