Research
We develop experimental methods for high-throughput microscopy and biochemical profiling of primary and human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Our computational approaches include large-scale regulatory network modeling and bioinformatic analysis of -omic data. Specific research focus areas include cardiomyocyte hypertrophy and death, extra-cellular matrix remodeling by fibroblasts and macrophages, and cardiomyocyte proliferation.
Automated image analysis of cardiac cells and tissue.
Selected publications
NETWORK MODEL-BASED SCREEN FOR FDA-APPROVED DRUGS AFFECTING CARDIAC FIBROSIS - PUBMED (NIH.GOV)
MECHANICAL REGULATION OF GENE EXPRESSION IN CARDIAC MYOCYTES AND FIBROBLASTS - PUBMED (NIH.GOV)
Publications
CSBG publications on PUBMED
Downloads
Our open-source software and computational models on GITHUB