Research

Heart function and failure are controlled by complex molecular networks that are just beginning to be mapped. The Cardiac Systems Biology Group combines computational modeling and experiments to discover molecular networks that control cardiac remodeling and regeneration.

We develop experimental methods for high-throughput microscopy and biochemical profiling of primary and human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Our computational approaches include large-scale regulatory network modeling and bioinformatic analysis of -omic data. Specific research focus areas include cardiomyocyte hypertrophy and death, extra-cellular matrix remodeling by fibroblasts and macrophages, and cardiomyocyte proliferation.

Automated image analysis of cardiac cells and tissue.

Automated image analysis of cardiac cells and tissue.

Computational modeling of cardiac signaling networks.

Selected publications

 

NETWORK MODEL-BASED SCREEN FOR FDA-APPROVED DRUGS AFFECTING CARDIAC FIBROSIS - PUBMED (NIH.GOV)

NETWORK ANALYSIS REVEALS A DISTINCT AXIS OF MACROPHAGE ACTIVATION IN RESPONSE TO CONFLICTING INFLAMMATORY CUES - PUBMED (NIH.GOV)

MECHANICAL REGULATION OF GENE EXPRESSION IN CARDIAC MYOCYTES AND FIBROBLASTS - PUBMED (NIH.GOV)

HIGH-CONTENT PHENOTYPIC ASSAY FOR PROLIFERATION OF HUMAN IPSC-DERIVED CARDIOMYOCYTES IDENTIFIES L-TYPE CALCIUM CHANNELS AS TARGETS - PUBMED (NIH.GOV)

 

Publications

CSBG publications on PUBMED

Downloads

Our open-source software and computational models on GITHUB