Publications

2025 

• Austeja Staneviciute, Debora B. Scariot, Yu-Gang Liu, Yuan Qian, Swagat Sharma, El Hadji Arona Mbaye, Sultan Almunif, David M. Engman, and Evan A. Scott (2025) Dual Treatment of Chronic Chagasic Cardiomyopathy and Parasitic Burden via Combination Nanotherapy, ACS Nano, DOI: 10.1021/acsnano.5c00669
• Debora B. Scariot, Austeja Staneviciute, Rayanne R.B. Machado, Simseok Yuk, Yu Gang Liu, Swagat Sharma, Sultan Almunif, El Hadji Arona Mbaye, Celso Vataru Nakamura, David M. Engman, Evan A. Scott (2025) Efficacy of Benznidazole Delivery During Chagas Disease Nanotherapy is Dependent on the Nanocarrier Morphology, Biomaterials, https://doi.org/10.1016/j.biomaterials.2025.123358.
• Chun Tang, Ruihua Zhang, Sultan Almunif, Partha Jyoti Das, Paige J Brown, Ryan M Young, Guangcheng Wu, Han Han, Xueze Zhao, Arthur HG David, Huang Wu, Bo Song, Alexandre Abhervé, Yong Wu, Yu-Meng Ye, Yuanning Feng, Aspen X-Y Chen, Charlotte L Stern, Zhi Li, Evan A Scott, Michael R Wasielewski, J Fraser Stoddart (2025) A compact catenane with tuneable mechanical chirality. Nat. Synth. https://doi.org/10.1038/s44160-025-00781-z
• El Hadji Arona Mbaye, Evan A Scott, Jacqueline A Burke (2025) From Edmonton to Lantidra and beyond: immunoengineering islet transplantation to cure type 1 diabetes, Frontiers in Transplantation, https://doi.org/10.3389/frtra.2025.1514956

2024 

• Pennock ND, Huynh R, Yuk S, et al. 1129 A mixed lineage kinase domain-like derived fusion protein resulting in inescapable immunogenic cell death for use in nanoparticle delivered cancer gene therapy (2024) Journal for ImmunoTherapy of Cancer 2024;12:doi: 10.1136/jitc-2024-SITC2024.1129
• M. DeBerge, S. Schroth, F. Du, X.Y. Yeap, J. Wang, Z.J. Zhang, M.J. Ansari, E.A. Scott, & E.B. Thorp (2024) Hypoxia inducible factor 2α promotes tolerogenic macrophage development during cardiac transplantation through transcriptional regulation of colony stimulating factor 1 receptor, Proc. Natl. Acad. Sci. U.S.A. 121 (26) e2319623121, https://doi.org/10.1073/pnas.2319623121
• Du, F., Rische, C.H., Li, Y. et al. Controlled adsorption of multiple bioactive proteins enables targeted mast cell nanotherapy. Nat. Nanotechnol. 19, 698–704 (2024). https://doi.org/10.1038/s41565-023-01584-z
• Klug N, Burke J, Scott E. Rational Engineering of Islet Tolerance via Biomaterial-Mediated Immune Modulation. J Immunol. 2024 Jan 15;212(2):216-224. doi: 10.4049/jimmunol.2300527. PMID: 38166244; PMCID: PMC10766078.

2023 

• Eva Morgun, Jennifer Zhu, Sultan Almunif, Sharan Bobbala, Melissa S Aguilar, Junzhong Wang, Kathleen Conner, Yongyong Cui, Liang Cao, Chetan Seshadri, Evan A Scott, Chyung-Ru Wang (2023) Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells eLife 12:RP87431, https://doi.org/10.7554/eLife.87431.3
• Bishop, Boaz; Sharma, Swagat; Scott, Evan. Nanomedicine in kidney disease. Current Opinion in Nephrology and Hypertension 32(4):p 366-376, July 2023. | DOI: 10.1097/MNH.0000000000000897
• Chamille Lescott, Sharan Bobbala, Mallika Modak, Roberto dos Reis, Evan A Scott, Vinayak P Dravid, Multimodal STEM Investigation of Polymer Damage Processes Induced by Electron Beam Irradiation, Microscopy and Microanalysis, Volume 29, Issue 1, February 2023, Pages 16–26, https://doi.org/10.1093/micmic/ozac023
• Bhushan NP, Stack T, Scott EA, Shull KR, Mathew B, Bijukumar D. In vitro assessment of varying peptide surface density on the suppression of angiogenesis by micelles displaying αvβ3 blocking peptides. J Biomed Mater Res. 2023; 111(2): 343-353. doi:10.1002/jbm.b.35154

• Hayden M Pagendarm, Payton T Stone, Blaise R Kimmel, Jessalyn J Baljon, Mina H Aziz, Lucinda E Pastora, Lauren Hubert, Eric W Roth, Sultan Almunif, Evan A Scott, John T Wilson (2023) Engineering endosomolytic nanocarriers of diverse morphologies using confined impingement jet mixing, Nanoscale,15.16016

  2022 

• Vincent MP, Navidzadeh JO, Bobbala S, Scott EA. Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy. Cancer Cell. 2022 Mar 14;40(3):255-276. doi: 10.1016/j.ccell.2022.01.006. Epub 2022 Feb 10. PMID: 35148814; PMCID: PMC8930620.
• Freire Haddad H, Burke JA, Scott EA, Ameer GA. Clinical Relevance of Pre-Existing and Treatment-Induced Anti-Poly(Ethylene Glycol) Antibodies. Regen Eng Transl Med. 2022;8(1):32-42. doi: 10.1007/s40883-021-00198-y. Epub 2021 Mar 25. PMID: 33786367; PMCID: PMC7993857.
• Scariot DB, Staneviciute A, Zhu J, Li X, Scott EA, Engman DM. Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases? Front Cell Infect Microbiol. 2022 Sep 16;12:1000972. doi: 10.3389/fcimb.2022.1000972. PMID: 36189341; PMCID: PMC9523166.
• Scott EA, Mooney DJ. A combination microparticle strategy for achieving antigen-specific tolerance. Proc Natl Acad Sci U S A. 2022 Dec 27;119(52):e2216976119. doi: 10.1073/pnas.2216976119. Epub 2022 Dec 19. PMID: 36534804; PMCID: PMC9907064.
• Burke JA, Zhang X, Bobbala S, Frey MA, Bohorquez Fuentes C, Freire Haddad H, Allen SD, Richardson RAK, Ameer GA, Scott EA. Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability. Nat Nanotechnol. 2022 Mar;17(3):319-330. doi: 10.1038/s41565-021-01048-2. Epub 2022 Jan 17. PMID: 35039683; PMCID: PMC8934301.
• Barman S, Borriello F, Brook B, Pietrasanta C, De Leon M, Sweitzer C, Menon M, van Haren SD, Soni D, Saito Y, Nanishi E, Yi S, Bobbala S, Levy O, Scott EA, Dowling DJ. Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers. ACS Chem Biol. 2022 Sep 16;17(9):2559-2571. doi: 10.1021/acschembio.2c00497. Epub 2022 Aug 26. PMID: 36028220; PMCID: PMC9486804.
• Yi S, Kim SY, Vincent MP, Yuk SA, Bobbala S, Du F, Scott EA. Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells. iScience. 2022 Jun 8;25(7):104555. doi: 10.1016/j.isci.2022.104555. PMID: 35769884; PMCID: PMC9234717.

• Bhushan NP, Stack T, Scott EA, Shull KR, Mathew B, Bijukumar D. In vitro assessment of varying peptide surface density on the suppression of angiogenesis by micelles displaying αvβ3 blocking peptides. J Biomed Mater Res B Appl Biomater. 2023 Feb;111(2):343-353. doi: 10.1002/jbm.b.35154. Epub 2022 Aug 30. PMID: 36054456; PMCID: PMC9771939.

  2021

• Soni D, Bobbala S, Li S, Scott EA, Dowling DJ. The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems. Pediatr Res. 2021 May;89(6):1364-1372. doi: 10.1038/s41390-020-01112-y. Epub 2020 Sep 14. PMID: 32927471; PMCID: PMC7511675.
• Li X, Yi S, Scariot DB, Martinez SJ, Falk BA, Olson CL, Romano PS, Scott EA, Engman DM. Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection. JCI Insight. 2021 May 10;6(9):e145523. doi: 10.1172/jci.insight.145523. PMID: 33986194; PMCID: PMC8262286.
• Vincent MP, Stack T, Vahabikashi A, Li G, Perkumas KM, Ren R, Gong H, Stamer WD, Johnson M, Scott EA. Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. ACS Appl Mater Interfaces. 2021 Jul 21;13(28):32823-32836. doi: 10.1021/acsami.1c09294. Epub 2021 Jul 7. PMID: 34232612; PMCID: PMC9131393.
• Bobbala S, Vincent MP, Scott EA. Just add water: hydratable, morphologically diverse nanocarrier powders for targeted delivery. Nanoscale. 2021 Jul 8;13(26):11349-11359. doi: 10.1039/d1nr02188e. PMID: 34160529; PMCID: PMC8343964.
• Vincent MP, Bobbala S, Karabin NB, Frey M, Liu Y, Navidzadeh JO, Stack T, Scott EA. Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets. Nat Commun. 2021 Jan 28;12(1):648. doi: 10.1038/s41467-020-20886-7. PMID: 33510170; PMCID: PMC7844416.
• Li S, Bobbala S, Vincent MP, Modak M, Liu Y, Scott EA. Pi-stacking Enhances Stability, Scalability of Formation, Control over Flexibility and Circulation Time of Polymeric Filaments. Adv Nanobiomed Res. 2021 Nov;1(11):2100063. doi: 10.1002/anbr.202100063. Epub 2021 Aug 5. PMID: 34870281; PMCID: PMC8635300.
• Allen ME, Golding A, Rus V, Karabin NB, Li S, Lescott CJ, Bobbala S, Scott EA, Szeto GL. Targeted Delivery of Chloroquine to Antigen-Presenting Cells Enhances Inhibition of the Type I Interferon Response. ACS Biomater Sci Eng. 2021 Dec 13;7(12):5666-5677. doi: 10.1021/acsbiomaterials.1c01047. Epub 2021 Nov 23. PMID: 34813288.

• Vincent MP, Karabin NB, Allen SD, Bobbala S, Frey MA, Yi S, Yang Y, Scott EA. The Combination of Morphology and Surface Chemistry Defines the Immunological Identity of Nanocarriers in Human Blood. Adv Ther (Weinh). 2021 Aug;4(4):2100062. doi: 10.1002/adtp.202100062. Epub 2021 Jun 13. PMID: 34485684; PMCID: PMC8411909.

  2020

• Modak M, Frey MA, Yi S, Liu Y, Scott EA. Employment of targeted nanoparticles for imaging of cellular processes in cardiovascular disease. Curr Opin Biotechnol. 2020 Dec;66:59-68. doi: 10.1016/j.copbio.2020.06.003. Epub 2020 Jul 15. PMID: 32682272; PMCID: PMC7744313.
• Du F, Qiao B, Nguyen TD, Vincent MP, Bobbala S, Yi S, Lescott C, Dravid VP, Olvera de la Cruz M, Scott EA. Homopolymer self-assembly of poly(propylene sulfone) hydrogels via dynamic noncovalent sulfone-sulfone bonding. Nat Commun. 2020 Sep 29;11(1):4896. doi: 10.1038/s41467-020-18657-5. PMID: 32994414; PMCID: PMC7525563.
• Davis JL, Zhang Y, Yi S, Du F, Song KH, Scott EA, Sun C, Zhang HF. Super-Resolution Imaging of Self-Assembled Nanocarriers Using Quantitative Spectroscopic Analysis for Cluster Extraction. Langmuir. 2020 Mar 10;36(9):2291-2299. doi: 10.1021/acs.langmuir.9b03149. Epub 2020 Feb 25. PMID: 32069413; PMCID: PMC7445082.
• Modak M, Bobbala S, Lescott C, Liu YG, Nandwana V, Dravid VP, Scott EA. Magnetic Nanostructure-Loaded Bicontinuous Nanospheres Support Multicargo Intracellular Delivery and Oxidation-Responsive Morphological Transitions. ACS Appl Mater Interfaces. 2020 Dec 16;12(50):55584-55595. doi: 10.1021/acsami.0c15920. Epub 2020 Dec 1. PMID: 33259182.
• Liu W, Bobbala S, Stern CL, Hornick JE, Liu Y, Enciso AE, Scott EA, Stoddart JF. XCage: A Tricyclic Octacationic Receptor for Perylene Diimide with Picomolar Affinity in Water. J Am Chem Soc. 2020 Feb 12;142(6):3165-3173. doi: 10.1021/jacs.9b12982. Epub 2020 Feb 4. PMID: 31944691.
• Bobbala S, Allen SD, Yi S, Vincent M, Frey M, Karabin NB, Scott EA. Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off-on cytotoxicity. Nanoscale. 2020 Mar 5;12(9):5332-5340. doi: 10.1039/c9nr10921h. PMID: 32090217; PMCID: PMC7197099.
• Yi S, Karabin NB, Zhu J, Bobbala S, Lyu H, Li S, Liu Y, Frey M, Vincent M, Scott EA. An Injectable Hydrogel Platform for Sustained Delivery of Anti-inflammatory Nanocarriers and Induction of Regulatory T Cells in Atherosclerosis. Front Bioeng Biotechnol. 2020 Jun 5;8:542. doi: 10.3389/fbioe.2020.00542. PMID: 32582667; PMCID: PMC7289959.
• Nagaraj R, Stack T, Yi S, Mathew B, Shull KR, Scott EA, Mathew MT, Bijukumar DR. High Density Display of an Anti-Angiogenic Peptide on Micelle Surfaces Enhances Their Inhibition of αvβ3 Integrin-Mediated Neovascularization In Vitro. Nanomaterials (Basel). 2020 Mar 22;10(3):581. doi: 10.3390/nano10030581. PMID: 32235802; PMCID: PMC7153711.