Alexander L (Sasha) Klibanov

Associate Professor

Contact

sasha@virginia.edu

Mobile

(434) 243-9773

Location

MR4, Room 3147, 409 Lane Rd

Lab

MR4, Room 3147

Klibanov Lab Cardiovascular Research Center PubMed

About

Born and raised and educated (all the way past Ph.D.) in Moscow, then USSR, what is now Russia. In 1991 moved to USA and worked in academic research and industrial positions. Research interests are in the area of chemistry applications in biomedical research.

Ultrasound imaging is a widespread and inexpensive non-invasive diagnostic technique. Ultrasound contrast agents offer a flexible platform that can be used for diagnostic imaging as a blood pool marker (tissue perfusion), as a targeted marker for imaging of inflammation, angiogenesis, and also as adjunct microdevices for enhanced targeted drug delivery and gene therapy. In diagnostic imaging, detection of contrast material offers high sensitivity (individual micron-sized particles can be visualized in vitro and in vivo by ultrasound medical imaging systems). We prepare and analyze such ultrasound contrast materials, attach targeting ligands (antibodies, peptides) and plasmid DNA to their surface for targeting and ultrasound-enhanced delivery. Using colloid chemistry-based approaches, stable microbubbles with extended circulation lifetime are designed; polymer brush coating is applied to ensure enhanced stability.

Education

B.S. Moscow University Chemistry Department

M.S. Moscow University Chemistry Department, 1979

Ph.D. National Cardiology Research Center, Academy of Medical Sciences, Moscow, USSR (Russia) 1984

Post-Doc University of Tennessee (Biochemistry), University of Pittsburgh (Pharmacology)

Klibanov lab has been active in pre-clinical research in the field of targeted imaging and drug delivery for over 25 years.

Alexander L (Sasha) Klibanov, Associate Professor

Research Interests

Medical and Molecular Imaging

Biotechnology and Biomolecular Engineering (Biomolecular Design, Cellular and Molecular Bioengineering)

Drug Delivery

Selected Publications

Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications. Invest Radiol. 2006 Mar;41(3):354-62. Klibanov AL

Ultrasound-microbubble-induced neovascularization in mouse skeletal muscle. Ultrasound Med Biol. 2005 Oct;31(10):1411-22. Chappell Jc, Klibanov Al, Price Rj.

Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging. Bioconjug Chem. 2005 Jan-Feb;16(1):9-17. Klibanov AL

Molecular imaging with targeted ultrasound contrast microbubbles. Ernst Schering Res Found Workshop. 2005;(49):171-91. Klibanov AL

Courses Taught

BME 3090 IDEAS Lab (Liposome Module, 2-3 Weeks)

Awards

Torsten Almen Award Contrast Media Research Symposium, 2013

Featured Grants & Projects

Klibanov Lab Projects Dr. Klibanov's lab has been active in pre-clinical research in the field of targeted imaging and drug delivery for over 25 years. Their main research interests are as follows: Molecular imaging contrast agents - preparation and characterization, ligand immobilization and targeting of particulate agents, microbubbles; Ultrasound contrast imaging - ultrasound-assisted drug delivery with drug-carrying contrast materials, Liposomes -coupling of enzymes, proteins, antibodies and polymers to liposomes, Antibody-mediated liposome targeting in vitro and in vivo. Liposomes and immunoliposomes with prolonged blood circulation. Covalent coupling of chelating polymers to antibodies. Antibody labeling with isotopes of heavy metals: applications in radioimmunoimaging, MRI and time-resolved fluoroimmunoassays. Application of radiolabeled antibodies for in vivo targeting.