BioB.S. University of Iowa, 2004Ph.D. University of Virginia, 2010Post-Doc University of Kentucky, Department of Ophthalmology and Visual Sciences 2012
"We study the blinding disease age-related macular degeneration, utilizing the tools of immunology,molecular biology, and engineering."Bradley D. Gelfand, Ph.D., Assistant Professor
One major focus of our work is to study the cellular and molecular consequences of the blood supply in the eye. Specifically, we are interested in quantifying the biomechanical changes that occur in the choroidal vasculature in healthy and diseased eyes, and how these micro-environmental cues affect the biology and pathology of the eye. To accomplish this, we perform high-resolution 3-D microscopy to generate accurate maps of the human choroidal anatomy in health and in disease which is utilized for computational fluid dynamic modeling. To study the influence of choroidal hemodynamics on ocular health, we employ a sophisticated cell culture system which is capable of reproducing the hemodynamic environment of the human eye. In a related project, our research analyzes the molecular mechanisms which underlie development of age-related macular degeneration. One such pathway involves deficiency of the RNA processing enzyme DICER1. Specifically, we seek to determine how DICER1 deficiency promotes death of retinal cells and the consequences of DICER1 deficiency on aberrant blood vessel growth.
Dr. Gelfand graduated with a degree in Biomedical Engineering from the University of Iowa (Iowa City). He next attended the University of Virginia (Charlottesville) where he earned his Ph.D. also in Biomedical Engineering. Brad next joined the Ambati Laboratory at the University of Kentucky in 2010 as a Postdoc and joined the faculty in 2012. In 2016, Brad returned to UVA as a faculty member in the Department of Ophthalmology. When he's not in the lab, he enjoys spending time with his lovely wife Christen, daughters Morgan and Stella and his dogs Yoda and Luke.