Dr. Chongzhi Zang is an associate professor and resident faculty member in the Center for Public Health Genomics, University of Virginia. He holds faculty appointments in the Departments of Public Health Sciences, Biomedical Engineering, and Biochemistry and Molecular Genetics. He is also a faculty member in the UVA Cancer Center and the Data Science Institute.
Chongzhi did his undergraduate research in high-field laser physics with Jie Zhang at the Institute of Physics, Chinese Academy of Sciences, and his PhD research in computational epigenomics with Weiqun Peng at the George Washington University and Keji Zhao at the National Institutes of Health. Prior to joining UVA in 2016, he completed his postdoctoral training with Xiaole Shirley Liu at Harvard University's Dana-Farber Cancer Institute. Chongzhi is a computational biologist with expertise in cancer epigenomics. His research focuses on algorithm development for high-throughput genomic data analytics and integrative modeling of gene regulatory networks in mammalian cell systems.
Education
B.S., Physics, Peking University, 2005
Ph.D., Physics, The George Washington University, 2010
We develop computational methods and use data science approaches to study how genes work in the chromatin and how they dysfunction in diseases like cancer.
Chongzhi Zang
Research Interests
Biomedical Data Sciences
Bioinformatics Methodology Development
Epigenetics and Chromatin Biology
Transcriptional Regulation
Cancer Genomics and Epigenomics
Theoretical and Computational Biophysics
Selected Publications
Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions. Nature Communications 13, 2965 (2022)
Smith Rj*, Zhang H*, Hu Ss*, Yung T, Francis R, Lee L, Onaitis Mw, Dirks Pb, Zang C#, Kim T-h#
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk. Nature Genetics (2022)
Turner Aw*, Hu Ss*, Mosquera Jv, Ma Wf, Hodonsky Cj, Wong D, Auguste G, Song Y, ..., Zang C#, Miller#
UTX condensation underlies its tumour-suppressive activity. Nature 597, 726–731 (2021)
Shi B*, Li W*, Song Y*, Wang Z*, Ju R, Ulman a, Hu J, Palomba F, Zhao Y, Le Jp, Jarrard W, Dimoff D, Digman Ma, Gratton E, Zang C, Jiang H
BARTweb: a web server for transcriptional regulator association analysis. NAR Genomics and Bioinformatics 3(2), lqab022 (2021)
Ma W*, Wang Z*, Zhang Y, Magee Ne, Feng Y, Shi R, Chen Y, Zang C
BART3D: Inferring transcriptional regulators associated with differential chromatin interactions from Hi-C data. Bioinformatics 37, 3075–3078 (2021)
Wang Z, Zhang Y, Zang C
Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements. iScience 23, 101518 (2020)
Chen D*, Chen Qy*, Wang Z*, Zhu Y, Kluz T, Tan W, Li J, Wu F, Fang L, Zhang X, He R, Shen S, Sun H, Zang C#, Jin C#, Costa M#
BART: a transcription factor prediction tool with query gene sets or epigenomic profiles. Bioinformatics, bty194 (2018)
Wang Z, Civelek M, Miller Cl, Sheffield Nc, Guertin Mj, Zang C
Cistrome Cancer: a web resource for integrative gene regulation modeling in cancer. Cancer Research 77, e19–e22 (2017)
Mei S, Meyer Ca, Zheng R, Qin Q, Wu Q, Jiang P, Li B, Shi X, Wang B, Fan J, Shih C, Brown M, Zang C#, Liu Xs#
