Contact
Location
West Complex, Room 6131C
Google Scholar Zang Lab Website

About

Dr. Chongzhi Zang is a Professor in the Department of Genome Sciences, with courtesy appointments in the Departments of Biomedical Engineering and Biochemistry and Molecular Genetics. He is the inaugural Director of Computational Genomics at the UVA Comprehensive Cancer Center.

Chongzhi is a computational biologist with expertise in cancer epigenetics and chromatin biology. His research focuses on developing computational methods for high-throughput genomics data analysis and using data science approaches to study chromatin and transcriptional regulation in mammalian cell systems and human diseases including cancer. With a training background in physics, Chongzhi did his undergraduate research in high-field laser physics with Jie Zhang at the Institute of Physics, Chinese Academy of Sciences, and his PhD research in biological physics and computational epigenomics with Weiqun Peng at the George Washington University and Keji Zhao at the National Institutes of Health. Prior to joining UVA in 2016, he completed his postdoctoral training with Xiaole Shirley Liu at Harvard University's Dana-Farber Cancer Institute.

Education

B.S., Physics, Peking University, 2005

Ph.D., Physics, The George Washington University, 2010

Postdoc, Computational Biology, Harvard University, 2016

Using innovative computational approaches, we aim to uncover the fundamental principles hidden behind the vast data generated by emerging biotechnologies, to advance biology towards a more quantitative science, and to help guide precision medicine to improve human health.

Chongzhi Zang

Research Interests

Biomedical Data Sciences
Method Development
Chromatin Biology and Epigenetics
Transcriptional Regulation
Cancer Genomics
Theoretical and Computational Biophysics

Selected Publications

PATTY corrects open-chromatin bias for improved bulk and single-cell CUT&Tag profiling. Nature Communications (2026) Hu SS, Su Z, Liu L, Chen Q, Grieco MC, Tian M, Dutta A, Zang C
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Genomic clustering tendency of transcription factors reflects phase-separated transcriptional condensates at super-enhancers. Nucleic Acids Research 53, gkaf015 (2025) Wang Z*, Wang S*, Zang C
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Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate. Science Immunology 10, eadq8970 (2025) Zhao X*, Hu SS*, ... Zang C#, Ma X#, Xue HH#
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An aberrant immune–epithelial progenitor niche drives viral lung sequelae. Nature 634, 961–969 (2024) Narasimhan H*, Cheon IS*, Qian W*, Hu SS*, Parimon T*, ..., Zang C#, Chen P#, Sun J#
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Intrinsic bias estimation for improved analysis of bulk and single-cell chromatin accessibility profiles using SELMA. Nature Communications 13, 5533 (2022) Hu SS, Liu L, Li Q, Ma W, Guertin MJ, Meyer CA, Deng K, Zhang T, Zang C
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Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions. Nature Communications 13, 2965 (2022) Smith RJ*, Zhang H*, Hu SS*, Yung T, Francis R, Lee L, Onaitis MW, Dirks PB, Zang C#, Kim T-H#
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Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk. Nature Genetics (2022) Turner AW*, Hu SS*, Mosquera JV, Ma WF, Hodonsky CJ, Wong D, Auguste G, Song Y, ..., Zang C#, Miller#
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Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses. Nature Immunology 23, 386–398 (2022) Shan Q*, Hu SS*, Zhu S, Chen X, Badovinac VP, Peng W, Zang C#, Xue HH#
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UTX condensation underlies its tumour-suppressive activity. Nature 597, 726–731 (2021) Shi B*, Li W*, Song Y*, Wang Z*, Ju R, Ulman A, Hu J, Palomba F, Zhao Y, Le JP, Jarrard W, Dimoff D, Digman MA, Gratton E, Zang C, Jiang H
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BARTweb: a web server for transcriptional regulator association analysis. NAR Genomics and Bioinformatics 3(2), lqab022 (2021) Ma W*, Wang Z*, Zhang Y, Magee NE, Feng Y, Shi R, Chen Y, Zang C
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BART3D: Inferring transcriptional regulators associated with differential chromatin interactions from Hi-C data. Bioinformatics 37, 3075–3078 (2021) Wang Z, Zhang Y, Zang C
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BART Cancer: a web resource for transcriptional regulators in cancer genomes. NAR Cancer 3, zcab011 (2021) Thomas ZV, Wang Z, Zang C
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Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation. Genome Biology 21, 247 (2020) Fang C*, Wang Z*, Han C, Safgren SL, Helmin KA, Adelman ER, Serafin V, Basso G, Eagen KP, Gaspar-Maia A, Figueroa ME, Singer BD, Ratan A, Ntziachristos P, Zang C
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BART: a transcription factor prediction tool with query gene sets or epigenomic profiles. Bioinformatics, bty194 (2018) Wang Z, Civelek M, Miller CL, Sheffield NC, Guertin MJ, Zang C
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Awards

Eminent Scholar Award, International Association for Intelligent Biology and Medicine 2026
Pinn Scholar Award 2024
School of Medicine Dean’s Award for Excellence in Research 2024
University of Virginia Research Excellence Award 2020
NIGMS Maximizing Investigators' Research Award (MIRA) 2019-2029
NCI Career Transition Award 2017-2020
Leukemia and Lymphoma Society Fellow Award 2012-2015
Dimitris N. Chorafas Foundation Prize 2010