George F. Rich
Harrison Medical Teaching Professor and Chair of Anesthesiology
Professor of Biomedical Engineering
About
George F. Rich, M.D. is the Harrison Medical Teaching Professor and Chair of Anesthesiology at the University of Virginia.
Education
B.S. Mechanical Engineering, University of Utah, 1979
M.D. University of Utah, 1985
Ph.D. Bioengineering, University of Utah, 1985
The UVA Department of Anesthesiology is committed to quality clinical care, outstanding educational offerings, and cutting edge research.
Research Interests
Cardiovascular Engineering
Selected Publications
"Endotoxin alters hypoxic pulmonary vasoconstriction in isolated rat lungs." Journal of Applied Physiology, 81:1316-1322, 1996.
D.U. Frank, S.M. Lowson, C.M. Roos, And G.F. Rich.
"Regulation of the endogenous NO pathway by prolonged inhaled NO in rats." Journal of Applied Physiology, 85:1070-1078, 1998.
D.U. Frank, D.J. Horstman, G.N. Morris, R.A. Johns, and G.F. Rich.
"Selective iNOS inhibition attenuates acetylcholine- and bradykinin-induced vasoconstriction in lipopolysaccharide-exposed rat lungs." Anesthesiology, 91:724-732, 1999.
L.G. Fischer, D.J. Horstman, K. Hahnenkamp, N.E. Kechner, And G.F. Rich.
Featured Grants & Projects
Effects of anesthesia on endothelium and vascular smooth muscle
Our research involves the role of endogenous nitric oxide/guanylate cyclase and other endothelial pathways in the control of vascular resistance. We are also interested in the effect of inhaled nitric oxide on pulmonary vascular resistance and its use in the treatment of pulmonary hypertension. Experiments are designed to model human diseases and to be clinically relevant. We perform acute and longterm experiments of induced pulmonary hypertension, utilizing a chronic hypoxia rat model. Other experiments include evaluation of inflammatory responses and the effects of inhibiting inducible endothelial enzymes, which may be partially responsible for sepsis-induced hypotension. Isolated lung and kidney models are used to study functional changes in vascular tone, associated with alterations of various endogenous endothelial pathways. We also evaluate protein and enzyme levels using western blots, light microscopy, and radioimmunoassays.