Bio

B.S. ​Laurea in Chemical Engineering, Universitá di Cagliari, Italy, 1980​M.Ch.E. in Chemical Engineering, University of Delaware, 1982​Ph.D. in Chemical Engineering, University of Delaware, 1984

"We employ experimental and theoretical engineering approaches to understand the fundamental underpinnings of chromatographic separations and develop new materials and processes for bioseparation applications. Our goal is to improve biopharmaceutical production by developing the science basis to fundamentally understand chromatographic purification of biomolecules at manufacturing scale."

Giorgio Carta, Lawrence R. Quarles Professor

Giorgio Carta received his PhD in Chemical Engineering from the University of Delaware in 1984 and is currently the Lawrence R. Quarles Professor in the Department of Chemical Engineering at the University of Virginia. He has published extensively in the area of adsorption and ion exchange with emphasis on protein chromatography. He has co-authored the book “Protein Chromatography – Process Development and Scale-Up," Wiley-VCH, 1st ed. 2010, 2nd ed. 2020, has served as section co-editor of Section 16 “Adsorption and Ion Exchange” of Perry's Chemical Engineers' Handbook, 7th, 8th, and 9th edition, and authored the textbook "Heat and Mass Transfer for Chemical Engineers: Principles and Applications," McGraw-Hill, 2021. He has served as member of the Organizing Committee of PREP International Symposium, Exhibit & Workshops on Preparative and Process Chromatography since 1997 and as Chair of the PREP Symposium annually since 2009. He is also involved extensively in professional education in the field of protein chromatography, including leading a short course in protein chromatography held twice a year at the University of Virginia. Giorgio Carta is an Editor of Biotechnology Journal and a member of the Editorial Board of Separation Science & Technology. He is a consultant for a number of chemical and pharmaceutical companies.

Awards

  • Elected Fellow of the American Institute of Medical and Biological Engineering 2002
  • Elected Fellow of the American Institute of Chemical Engineers 2007
  • All-University Teaching Award, University of Virginia 2008-2009
  • Robert A. Moore, Jr. Award in Chemical Engineering, University of Virginia 2008, 2010

Research Interests

  • Materials and Advanced Manufacturing for Biological Applications
  • Biotechnology and Biomolecular Engineering (Biomolecular Design, Cellular and Molecular Bioengineering)

Selected Publications

  • Heat and Mass Transfer for Chemical Engineers: Principles and Applications Carta, G, McGraw-Hill, New York, NY, 432 pages, August 2021
  • Protein Chromatography - Process Development and Scale-up (Second Edition) Carta, G., Jungbauer, A., Wiley-VCH, Weinheim, Germany, 432 pages, April 2020.
  • Adsorption and Ion Exchange LeVan, M.D. (Section Coeditor), Carta, G. (Section Coeditor), Ritter, J.A., Walton, K.A., Section16, in Perry's Chemical Engineers' Handbook, Ninth Edition, Green, D.W., Editor–in–Chief, McGraw–Hill, 2018.
  • Role of Configurational Flexibility on the Kinetics of Binding of Bivalent Bispecific Antibodies on Porous Cation Exchange Resins Kimerer, L.K, Pabst, T.M., Hunter, A.K., Carta, G., J. Chromatogr. A, 1655 (2021) 462479
  • Relationship between HETP measurements and breakthrough curves in short chromatography columns Roberts, J.A., Carta, G., Biotechnol. Progr., 37 (2021) e3065
  • Chromatographic and adsorptive behavior of a bivalent bispecific antibody and associated fragments Kimerer, L.K., Niu, B., Pabst, T.M., Zhai, W., Hunter, A.K., Carta, G., J. Chromatogr. A, 1648 (2021) 462181.
  • Protein Adsorption on Core-shell Particles: Comparison of CaptoTM Core 400 and 700 Resins Mi, X., Fuks, P., Wang, S.-C., Winters, M.A., Carta, G., J. Chromatogr. A, 1651 (2021) 462314.
  • Chromatographic behavior of bivalent bispecific antibodies on hydrophobic interaction chromatography columns Kimerer, L.K, Pabst, T.M., Hunter, A.K., Carta, G., J. Chromatogr. A, (2020) 460836.
  • Dynamics of Competitive Binding and Separation of Monoclonal Antibody Monomer-Dimer Mixtures in Ceramic Hydroxyapatite Columns Wang, Y., Carta, G., J. Chromatogr. A, 1609 (2020) 460504.
  • Chromatographic Behavior of Bivalent Bispecific Antibodies on Cation Exchange Columns. I. Experimental Observations and Phenomenological Model Kimerer, L.K, Pabst, T.M., Hunter, A.K., Carta, G., J. Chromatogr. A, 1601 (2019) 121-132.
  • Chromatographic Behavior of Bivalent Bispecific Antibodies on Cation Exchange Columns. II. Biomolecular Perspectives Kimerer, L.K, Pabst, T.M., Hunter, A.K., Carta, G., J. Chromatogr. A, 1601 (2019) 133-144.
  • Rapid and Sensitive Detection of the Interaction of Human Papillomavirus Virus-Like Particles with Yeast Whole Cell RNA using Biolayer Interferometry Wang, Y., Carta, G., Biotechnol. J., 14 (2019) Article no. 1800303.
  • Systematic Interpolation Method Predicts Antibody Monomer-Dimer Separation by Gradient Elution Chromatography at High Protein Loads Creasy, A., Reck, J., Pabst, T., Hunter, A., Barker, G., Carta, G., Biotechnol. J., 14 (2019) Article no. 1800132.
  • Competitive Binding of Monoclonal Antibody Monomer-Dimer Mixtures on Ceramic Hydroxyapatite Wang, Y., Carta, G., J. Chromatogr. A, 1587 (2019) 136–145.
  • Gradient Elution Behavior of Proteins in Hydrophobic Interaction Chromatography with U-Shaped Retention Factor Curves Creasy, A., Lomino, J., Barker, G., Khetan, A., Carta, G., J. Chromatogr. A, 1547 (2018) 53-61.
  • Protein Adsorption in Anion Exchange Resins – Effects of Polymer Grafting, Support Structure Porosity, and Protein Size Zhu, M., Fuks, P., Carta, G., J. Chem. Technol. Biotechnol., 93 (2018) 1948-1958.
  • Systematic interpolation method predicts protein chromatographic elution with salt gradients, pH gradients and combined salt/pH gradients Creasy, A., Barker, G., Carta, G., Biotechnol. J., 12 (2017) 1600636.
  • Separation of Antibody Monomer-Dimer Mixtures by Frontal Analysis Reck, J., Pabst, T., Hunter, A., Carta, G., , J. Chromatogr. A., 1500 (2017) 96.
  • Structural and Performance Characteristics of Representative Anion Exchange Resins Used for Weak Partitioning Chromatography Zhang, S., Iskra, T., Daniels, W, Salm, J., Gallo, C., Godavarti, R., Carta, G., Biotechnol. Progr., 33 (2017) 425.

Courses Taught

  • Engineering Concepts
  • Material and Energy Balances
  • Transport Phenomena I (Fluid Mechanics & Heat Transfer)
  • Transport Phenomena II (Mass Transfer & Unit Operations)
  • Transport Phenomena II (Heat & Mass Transfer)
  • Chemical Reaction Engineering
  • Chemical Process Simulation
  • Chemical Engineering Design
  • Chemical Engineering Laboratory
  • Bioseparations Engineering
  • Mass Transfer
  • Fluid Mechanics
  • Specialized Separation Processes