Bio

B.S. ​Laurea in Chemical Engineering, Universitá di Cagliari, Italy, 1980​M.Ch.E. in Chemical Engineering, University of Delaware, 1982​Ph.D. in Chemical Engineering, University of Delaware, 1984

"We employ experimental and theoretical engineering approaches to understand the fundamental underpinnings of chromatographic separations and develop new materials and processes for bioseparation applications. Our goal is to improve biopharmaceutical production by developing the science basis to fundamentally understand chromatographic purification of biomolecules at manufacturing scale."

Giorgio Carta, Lawrence R. Quarles Professor

Giorgio Carta received his PhD in Chemical Engineering from the University of Delaware in 1984 and is currently the Lawrence R. Quarles Professor in the Department of Chemical Engineering at the University of Virginia. He has published extensively in the area of adsorption and ion exchange with emphasis on protein chromatography. He has co-authored the book “Protein Chromatography – Process Development and Scale-Up”, Wiley (2010) and has served as section co-editor of Section 16 “Adsorption and Ion Exchange” of Perry's Chemical Engineers' Handbook, 7th, 8th, and 9th edition. He has served as member of the Organizing Committee of PREP International Symposium, Exhibit & Workshops on Preparative and Process Chromatography since 1997 and as Chair of the PREP Symposium annually since 2009. He is also involved extensively in professional education in the field of protein chromatography, including leading a short course in protein chromatography held twice a year at the University of Virginia. Giorgio Carta is an Editor of Biotechnology Journal and a member of the Editorial Board of Separation Science & Technology. He is a consultant for a number of chemical and pharmaceutical companies.

Awards

  • Elected Fellow of the American Institute of Medical and Biological Engineering 2002
  • Elected Fellow of the American Institute of Chemical Engineers 2007
  • All-University Teaching Award, University of Virginia 2008-2009
  • Robert A. Moore, Jr. Award in Chemical Engineering, University of Virginia 2008, 2010

Research Interests

  • Materials and Advanced Manufacturing for Biological Applications
  • Biotechnology and Biomolecular Engineering (Biomolecular Design, Cellular and Molecular Bioengineering)

Selected Publications

  • Protein Chromatography - Process Development and Scale-up Carta, G., Jungbauer, A., Wiley-VCH, Weinheim, Germany, 368 pages, April 2010.
  • Adsorption and Ion Exchange LeVan, M.D. (Section Coeditor), Carta, G. (Section Coeditor), Section16, in Perry's Chemical Engineers' Handbook, Eighth Edition, Green, D.W., Editor–in–Chief, McGraw–Hill, 2007.
  • Separation of Antibody Monomer-Dimer Mixtures by Frontal Analysis Reck, J., Pabst, T., Hunter, A., Carta, G., , J. Chromatogr. A., 1500 (2017) 96.
  • Systematic interpolation method predicts protein chromatographic elution with salt gradients, pH gradients and combined salt/pH gradients Creasy, A., Barker, G., Carta, G., Biotechnol. J., 12 (2017) 1600636.
  • Structural and Performance Characteristics of Representative Anion Exchange Resins Used for Weak Partitioning Chromatography Zhang, S., Iskra, T., Daniels, W, Salm, J., Gallo, C., Godavarti, R., Carta, G., Biotechnol. Progr., 33 (2017) 425.
  • Surface induced three-peak elution behavior of a monoclonal antibody during cation exchange chromatography Guo, J., Creasy, A.D., Barker, G., Carta, G., J. Chromatogr. A, 1474 (2016) 85-94.
  • Comparison of Perfusion Media and Monoliths for Protein and Virus-Like Particle Chromatography Yu, Y., Abraham, D., Carta, G., J. Chromatogr. A, 1447 (2016) 72-81.
  • Structural and Performance Characteristics of Virgin and Fouled Protein A MabSelect Resin Cycled in a Monoclonal Antibody Purification Process Zhang, S., Daniels, W., Salm, J., Glynn, J., Martin, J., Gallo, C., Godavarti, R., Carta, G., Biotechnol. Bioeng., 113 (2016) 367-375.
  • Nature of Foulants and Fouling Mechanism of the Protein A MabSelect Resin Cycled in a Monoclonal Antibody Purification Process Zhang, S., Xu, K., Daniels, W., Salm, J., Glynn, J., Martin, J., Gallo, C., Godavarti, R., Carta, G., Biotechnol. Bioeng., 113 (2016) 141-149.
  • Predicting Protein Chromatographic Elution from Batch Isotherm Data without a Mechanistic Isotherm Model Creasy, A., Xu, X., Barker, G., Carta, G., Biotechnol. J., 10 (2015) 1400-1411.
  • Adsorption Equilibrium and Kinetics of Monomer-Dimer Monoclonal Antibody Mixtures on a Cation Exchange Resin Reck, J., Pabst, T., Hunter, A., Wang, Y., Carta, G., J. Chromatogr. A, 1402 (2015) 46-59.
  • Resolution of Protein Charge Variants in Mixed-Bed Chromatography Columns with Step-Induced pH Gradients at High Protein Loadings Vetter, T.A., Ferreira, G., Robbins, D., Carta, G., Sep. Sci. Technol., 50 (2015) 2211.
  • Unfolding and Aggregation of a Glycosylated Monoclonal Antibody on a Cation Exchange Column- Part I. Chromatographic Elution and Batch Adsorption Behavior Guo, J., Zhang, S., Carta, G., J. Chromatogr. A, 1356 (2014) 117.
  • Unfolding and Aggregation of a Glycosylated Monoclonal Antibody on a Cation Exchange Column - Part II. Protein Structure Effects by Hydrogen Deuterium Exchange Mass Spectrometry Guo, J., Carta, G., J. Chromatogr. A, 1356 (2014) 129

Courses Taught

  • Engineering Concepts
  • Material and Energy Balances
  • Transport Phenomena I (Fluid Mechanics & Heat Transfer)
  • Transport Phenomena II (Mass Transfer & Unit Operations)
  • Transport Phenomena II (Heat & Mass Transfer)
  • Chemical Reaction Engineering
  • Chemical Process Simulation
  • Chemical Engineering Design
  • Chemical Engineering Laboratory
  • Bioseparations Engineering
  • Mass Transfer
  • Fluid Mechanics
  • Specialized Separation Processes