Bio

B.S. ​Missouri University of Science and Technology, 2004​Ph.D. University of Colorado, Boulder, 2009Post-Doc ​Stanford University, Materials Science and Engineering, 2010-2013

"We hope to better understand and treat diseases and injuries of the central nervous system, that is, the brain and spinal cord."

Kyle J. Lampe, Assistant Professor

Kyle is an Assistant Professor in the Department of Chemical Engineering at the University of Virginia, and by courtesy, Biomedical Engineering and Neuroscience. He was previously a Ruth L. Kirschstein NIH NRSA postdoctoral scholar at Stanford University with Prof. Sarah Heilshorn in the department of Materials Science and Engineering. Kyle completed his Ph.D. and B.S. in Chemical Engineering from the University of Colorado, Boulder and the Missouri University of Science and Technology (Rolla, MO), respectively. The Lampe Group investigates biomaterials for tissue engineering, regenerative medicine, and drug delivery within the central nervous system, developing both synthetic polymers and recombinant engineered proteins.

Awards

  • Translational Health Research Insitute of Virginia (THRIV) Mentored Career Development Award 2017
  • Postdoctoral Research Award – Stanford University Postdoctoral Association, Stanford University, School of Engineering recipient 2012
  • Ruth L. Kirschstein NIH NRSA Postdoctoral Fellowship 2011-2013
  • U.S. Dept. of Education – Graduate Assistantship in Areas of National Need (GAANN) 2005-2008

Research Interests

  • Biomaterials
  • Tissue Engineering and Regenerative Medicine
  • Materials and Advanced Manufacturing for Biological Applications
  • Drug Delivery
  • Biotechnology and Biomolecular Engineering (Biomolecular Design, Cellular and Molecular Bioengineering)
  • Bio-inspired systems

Selected Publications

  • "Toward a Designable Extracellular Matrix: Molecular Dynamics Simulations of an Engineered Laminin-Mimetic, Elastin-Like Fusion Protein," Biomacromolecules, 17: 3222–3233 (2016) ABS JD Tang, CE McAnany, C Mura, KJ Lampe
  • "Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses," Journal of Materials Chemistry B, 3: 7867-7880 (2015) ABS NP Murphy, KJ Lampe
  • "Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities," Small, 11: 722-730 (2015). ABS NH Romano, KJ Lampe, H Xu, MM Ferreira, SC Heilshorn
  • "Design of 3D engineered protein hydrogels for tailored control of neurite growth," Acta Biomaterialia, 9: 5590-5599 (2013) ABS KJ Lampe, AL Antaris, SC Heilshorn
  • "Tetrakis (hydroxyl methyl) phosphonium chloride as a covalent crosslinking agent for cell encapsulation within protein-based hydrogels," Biomacromolecules, 13: 3912-3916 (2012) ABS C Chung, KJ Lampe, SC Heilshorn
  • "Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers," Tissue Engineering Part A, 18: 806-815 (2012) ABS BA Aguado, W Mulyasasmita, J Su, KJ Lampe, SC Heilshorn
  • "The administration of BDNF and GDNF to the brain via PLGA microparticles patterned within a degradable PEG-based hydrogel: protein distribution and the glial response," Journal of Biomedical Materials Research Part A, 96A: 595-607 (2011) ABS KJ Lampe, DS Kern, MJ Mahoney, KB Bjugstad
  • "Impact of degradable macromer content in a poly(ethylene glycol) hydrogel on neural cell metabolic activity, redox state, proliferation, and differentiation," Tissue Engineering Part A, 16:1857-1866 (2010) ABS KJ Lampe, KB Bjugstad, MJ Mahoney
  • "Biocompatibility of PEG-Based Hydrogels in Primate Brain," Cell Transplantation, 17:409-417 (2008) ABS KB Bjugstad, DE Redmond, KJ Lampe, DS Kern, JR Sladek Jr, MJ Mahoney

Courses Taught

  • CHE 4449/6449 - Polymer Science and Engineering Fall Semester
  • CHE 3347/6447 - Biochemical Engineering Spring Semester

Featured Grants & Projects

  • Neural repair via self-assembling biomaterial hydrogels designed by molecular dynamic simulations


    The Thomas F. and Kate Miller Jeffress Memorial Trust and the Hazel Thorpe Carman and George Gay Carman Trust.

  • Bioengineered Hydrogels to Facilitate 3D Neural Stem Cell Survival and Growth in a Stroke Environment

    Mentored Careerd Development Award


    Translational Health Research Institute of Virginia (THRIV)