Contact
Office
(434) 924-0020
Location
MR5, 2316
Lab
MR5, 2214 and 2216 ​PO Box 800759, Health System

Richard J. Price

Nancy and Neal Wade Professor of Engineering & Applied Science Department of Biomedical Engineering Co-Director of the UVA Focused Ultrasound Cancer Immunotherapy Center
Contact
Office
(434) 924-0020
Location
MR5, 2316
Lab
MR5, 2214 and 2216 ​PO Box 800759, Health System
Price Lab Website UVA Focused Ultrasound Cancer Immunotherapy Center Google Scholar

About

Dr. Price's research program centers on the development and implementation of image-guided drug and gene delivery systems for treating cancer and neurodegenerative diseases. Several lines of investigation in the lab are derived from seminal studies demonstrating that microbubble activation with ultrasound can enable the delivery of therapeutic drug- and gene-bearing nanoparticles across endothelial barriers under MR image-guidance. Other projects in the lab investigate how minimally-invasive focused ultrasound energy deposition into solid tumors may be optimally combined with immunotherapy to treat metastatic disease. Research in this space supports ongoing UVA clinical trials for metastatic breast cancer and other solid malignancies. In his role as Research Director of the UVA Focused Ultrasound Center, he leads an institution-wide effort to identify, investigate, and translate new focused ultrasound applications.

Education

B.S. ​Rochester Institute of Technology, 1990

Ph.D. ​University of Virginia, 1995

The Price Laboratory develops image-guided drug and gene delivery approaches for cancer, neurodegenerative diseases, and cerebral cavernomas."

Research Interests

Drug and Gene Delivery
Medical and Molecular Imaging
Biomechanics and Mechanobiology
Cardiovascular Engineering

Selected Publications

MRI of Mouse Cerebral Cavernomas Reveals Differential Lesion Progression and Variable Permeability to Gadolinium. Arterioscler Thromb Vasc Biol. 43(6):958-970. 2023. FISHER, D.G., K.A. SHARIFI, E.Z. ULUTAS, J.S. KUMAR, M.Y.S. KALANI, G.W. MILLER, R.J. PRICE, P. TVRDIK
The Alzheimer's Disease Risk Factor INPP5D Restricts Neuroprotective Microglial Responses in Amyloid Beta-Mediated Pathology.Alzheimers Dement. doi: 10.1002/alz.13089. 2023. SAMUELS, J.D., K.A. MOORE, H.E. ENNERFELT, A.M. JOHNSON, A.E. WALSH, R.J. PRICE, AND J.R. LUKENS
Intraarterial Transplantation of Mitochondria After Ischemic Stroke Reduces Cerebral Infarction. Stroke Vasc Interv Neurol. e000644. 2023. NORAT, P, J.D. SOKOLOWSKI, C.M. GORICK, S. SOLDOZY, J.S. KUMAR, Y. CHAE, K. YAGMURLU, J. NILAK, K.A. SHARIFI, M. WALKER, M.R. LEVITT, A.L. KLIBANOV, Z. YAN, R.J. PRICE, P. TVRDIK, M.Y.S. KALANI
Solid Tumor Treatment Via Augmentation of Bioactive C6 Ceramide Levels with Thermally Ablative Focused Ultrasound. Drug Deliv Transl Res. doi: 10.1007/s13346-023-01377-w. 2023 THIM, E.A.,T. FOX, T. DEERING, L.R. VASS, N.D. SHEYBANI, M. KESTER, AND R.J. PRICE
Applications of Focused Ultrasound-Mediated Drug and Gene Delivery Across the Blood-Brain Barrier. Advanced Drug Delivery Reviews. 191:114583. 2022. GORICK, C.M., V.R. BREZA, K.M. NOWAK, V.W.T. CHENG, D.G. FISHER, A.C. DEBSKI, M.R. HOCH, Z.E.F. DEMIR, N.M. TRAN, M.R. SCHWARTZ, N.D. SHEYBANI, AND R.J. PRICE

Courses Taught

BME 2220 Biomechanics
BME 2102 Physiology II

Awards

Fellow of the Controlled Release Society 2021
Fellow of the Controlled Release Society 2017
Jorge Heller Award for Most Outstanding Paper in Journal of Controlled Release 2015
Fellow of the American Institue of Medical and Biological Engineering 2015