B.S. Rochester Institute of Technology, 1990Ph.D. University of Virginia, 1995
"The Price Laboratory develops image-guided drug and gene delivery approaches for cancer and neurodegenerative diseases."
Richard J. Price, Ph.D., is Professor of Biomedical Engineering at the University of Virginia. Early in his career, he performed seminal studies demonstrating that microbubble activation with ultrasound could be used to deliver nanoparticles across endothelial barriers. His current research centers on the use of MRI-guided focused ultrasound for targeting the delivery of drugs and genes across the blood-brain barrier for the treatment of brain tumors and the prevention of Parkinson’s neurodegeneration. He is also Research Director of the UVA Focused Ultrasound Center. In this capacity, he leads an institution-wide effort to identify, investigate, and translate new focused ultrasound applications.
Andrew J. Lockhart Memorial Prize for Focused Ultrasound Cancer Research2017
Jorge Heller Award for Most Outstanding Paper in Journal of Controlled Release 2015
Fellow of the American Institue of Medical and Biological Engineering2015
Sonoselective Transfection of Cerebral Vasculature Without Blood–Brain Barrier Disruption. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1914595117. 2020. Gorick, C.M., A.S. Mathew, W.J. Garrison, E.A. Thim, D.G. Fisher, C.A. Copeland, J. Song, A.L. Klibanov, G.W. Miller, and R.J. Price
Augmentation of Brain Tumor Interstitial Flow via Focused Ultrasound Promotes Brain-Penetrating Nanoparticle Dispersion and Transfection. Science Advances. DOI: 10.1126/sciadv.aay1344. 2020. Curley, C.T., B.P. Mead, K. Negron, N. Kim, W.J. Garrison, E.A. Thim, K.M. Kingsmore, J.M. Munson, G.W. Miller, A.L.Klibanov, J.S. Suk, J. Hanes, and R.J. Price
Focused Ultrasound Pre-Conditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System. Small. DOI: 10.1002/smll.201903460. 2019. Mead, B.P., C.T. Curley, N. Kim, K. Negron, W.J. Garrison, J. Song, D. Rao, G. Wilson Miller, J.W. Mandell, B.J. Purow, J.S. Suk, J. Hanes, and R.J. Price
Perspectives on Recent Progress in Focused Ultrasound Immunotherapy. Theranostics. DOI:10.7150/thno.37131. 2019. Sheybani, N.D. and R.J. Price
Parkinson's Disease Gene Therapy: Will Focused Ultrasound and Nanovectors be the Next Frontier? Movement Disorders. doi: 10.1002/mds.27675. 2019. Price R.J., D.G. Fisher, J.S. Suk, J. Hanes, H.S. Ko, J.H. Kordower
Epigenetic Regulators of the Revascularization Response to Chronic Arterial Occlusion.Cardiovascular Research. 115:701-712. 2019. Heuslein J.L., C.M.Gorick, R.J. Price
Recent Advances in the Use of Focused Ultrasound for MR Image-Guided Nanoparticle Delivery to the Central Nervous System. Frontiers in Pharmacology. 10:1348. 2019. Fisher, D.G., and R.J. Price
Listening in on the Microbubble Crowd: Advanced Acoustic Monitoring for Improved Control of Blood-Brain Barrier Opening with Focused Ultrasound. Theranostics. 8:2988-2991. 2018. Gorick C.M., N.D. Sheybani, C.T. Curley, R.J. Price
Exposure of Endothelium to Biomimetic Flow Waveforms Yields Identification of miR-199a as a Potent Regulator of Arteriogenesis. Molecular Therapy: Nucleic Acids. 12:829-844. 2018. Heuslein, J.L., C.M. Gorick, S.P. McDonnell, J. Song, B.H. Annex, and R.J. Price
Novel focused ultrasound gene therapy approach non-invasively restores dopaminergic neuron function in a rat Parkinson’s disease model. Nano Lett. 17:3533-3542; 2017. Mead, B.P., N. Kim, G.W. Miller, D. Hodges, P. Mastorakos, A.L. Klibanov, J.W. Mandell, J. Hirsh, J.S. Suk, J. Hanes, R.J. Price
MR Image-Guided Delivery of Cisplatin-Loaded Brain-Penetrating Nanoparticles to Invasive Glioma with Focused Ultrasound. J Control Release. 263:120-131; 2017. Timbie, K.F., U. Afzal, A. Date, C. Zhang, J. Song, G.W. Miller, J.S. Suk, J. Hanes, and R.J. Price
Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities. Theranostics. doi:10.7150/thno.21225. 2017. Curley, C.T., N.D. Sheybani, T.N. Bullock, and R.J. Price
DNA Methyltransferase 1–Dependent DNA Hypermethylation Constrains Arteriogenesis by Augmenting Shear Stress Set Point. J Am Heart Assoc. 6:e007673. 2017. Heuslein, J.L., C.M. Gorick, J. Song, and R.J. Price
Targeted Gene Transfer to the Brain via the Delivery of Brain-Penetrating DNA Nanoparticles with Focused Ultrasound. J Control Rel. 223: 109-117. 2016. Mead, B.P., P. Mastorakos, J.S. Suk, A.L. Klibanov, J. Hanes, and R.J. Price.
Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion. Scientific Reports. 6: 27029. 2016. Heuslein, J.L., K.P. Murrell, R.J. Leiphart, J.K. Meisner, R.A. Llewellyn, and R.J. Price.
Drug and Gene Delivery Across the Blood-Brain Barrier with Focused Ultrasound. J Control Rel. 219:61-75. 2015. Timbie, K.F., B.P. Mead, and R.J. Price
Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Reversed Flow Direction. Arterioscler Thromb & Vasc Biol. 35: 2354-2365. 2015. Heuslein, J.L., J.K. Meisner, R. J. Leiphart, X. Li, J. Song, H. Vincentelli, E.G. Ames, B.R. Blackman, and R.J. Price.
Noninvasive Delivery of Stealth Brain Penetrating Nanoparticles Across the Blood-Brain Barrier with MR Image-Guided Focused Ultrasound. J Control Rel. 189:123-132. 2014. E. Nance, K.F. Timbie, G.W. Miller, J. Song, C. Louttit, A.L. Klibanov, T-Y Shih, G. Swaminathan, G. Woodworth, J. Hanes and R.J. Price.
Ultrasound-Activated Agents Comprised of 5FU-Bearing Nanoparticles Bonded to Microbubbles Inhibit Solid Tumor Growth and Improve Survival. Molecular Therapy. 22:321-8. 2014. Burke, C.W., K. Timbie, E. Alexander IV, A.L. Klibanov, J.P. Sheehan, and R.J. Price.