​M.D. Biejing Medical University, China, 1987

"We seek to explain the role of inflammatory mediators during the genesis of iscemia/reperfusion injury."

Zequan Yang, Associate Professor of Cardiovascular Medicine and Biomedical Engineering

As a highly capable and compassionate physician, and well-trained in the area of general surgery, Dr.Yang brings dedication to providing the highest quality of patient care both within the office and hospital at all times without compromise. His utmost concern is with how the patient feels, and will treat them as if they were his family.

Research Interests

  • Biotechnology and Biomolecular Engineering (Biomolecular Design, Cellular and Molecular Bioengineering)
  • Cardiovascular Engineering

Selected Publications

  • The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A 2A receptors., 2015; Basic research in cardiology. 110(2) 16. ABS Tian Y, Marshall M, French BA, Linden J, Yang Z
  • Atorvastatin at reperfusion reduces myocardial infarct size in mice by activating eNOS in bone marrow-derived cells., 2014; PloS one. 9(12) e114375. ABS Tian Y, Linden J, French BA, Yang Z
  • Acute hyperglycemia abolishes ischemic preconditioning by inhibiting Akt phosphorylation: normalizing blood glucose before ischemia restores ischemic preconditioning., 2013; Oxidative medicine and cellular longevity. 2013() 329183. ABS Yang Z, Tian Y, Liu Y, Hennessy S, Kron IL, French BA
  • Phospholemman deficiency in postinfarct hearts: enhanced contractility but increased mortality., 2012; Clinical and translational science. 5(3) 235-42. ABS Mirza MA, Lane S, Yang Z, Karaoli T, Akosah K, Hossack J, McDuffie M, Wang J, Zhang XQ, Song J, Cheung JY, Tucker AL
  • Gastropexy using the Carter-Thomason device in lieu of T-fasteners in a critically ill, severely obese patient: an innovative technique., 2012; Surgical laparoscopy, endoscopy & percutaneous techniques. 22(5) e316-8. ABS Rosenberger LH, Hu Y, Yang Z, Sawyer RG
  • Synthesis of PECAM-1-specific 64Cu PET imaging agent: evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse., 2012; Bioorganic & medicinal chemistry letters. 22(12) 4144-7. ABS Xiao L, Zhang Y, Yang Z, Xu Y, Kundu B, Chordia MD, Pan D
  • Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice., 2011; The Journal of clinical investigation. 122(1) 70-9. ABS Alexander MR, Moehle CW, Johnson JL, Yang Z, Lee JK, Jackson CL, Owens GK
  • Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution., 2010; Gene therapy. 18(1) 43-52. ABS Prasad KM, Xu Y, Yang Z, Acton ST, French BA
  • Smooth muscle phenotypic modulation is an early event in aortic aneurysms., 2009; The Journal of thoracic and cardiovascular surgery. 138(6) 1392-9. ABS Ailawadi G, Moehle CW, Pei H, Walton SP, Yang Z, Kron IL, Lau CL, Owens GK

Featured Grants & Projects

  • UVA Surgical Care Projects

    We seek to elucidate the role of inflammatory mediators during the genesis of ischemia/ reperfusion injury. An interdisciplinary approach is used to integrate advanced surgical techniques with cardiovascular physiology and pharmacology. Recently knockout mice were used to evaluate the effects of endogenous IL-10 and poly (ADP-ribose) synthetase on myocardial infarction. Transgenic and knockout mice can help define the various inflammatory pathways that contribute to the myocardial injury induced by ischemia and reperfusion. We are currently extending our research focus from myocardial infarction to encompass the post-infarction state of heart failure. Reliable models of heart failure have been established in mice and rats. These animal models are currently being validated using cardiac MRI. The longterm goal of this research is to test innovative new therapies for the prevention of heart failure. We are also working in collaboration with other faculty to optimize methods for delivering genes directly to the intact myocardium of rats and mice. The ultimate aim of these efforts is to maintain cardiac function after myocardial infarction by using gene therapy to inhibit the inflammatory responses that exacerbate heart failure.