A fundamental breakthrough behind tech giants like Google, Amazon and Facebook is straightforward: Their founders realized they could power business using data science. The ability to aggregate and analyze data from billions of users has set the stage for a host of disruptive products and services. This realization, of course, has reverberated through every sector of the economy, including medicine and healthcare. Whether they discover new drugs, improve medical imaging, produce medical devices, or deliver care for patients, organizations are making enormous investments in data science as a way to deliver better care to more people with unprecedented speed, precision and efficiency. For at least the next generation, data science will define the field.