Associate Professor of Biomedical Engineering Jeffrey Saucerman's work illustrates the versatility of computational methods. Saucerman is dedicated to finding ways to treat heart failure, an irreversible, inevitably fatal condition that afflicts five million Americans. Saucerman and the members of his Cardiac Systems Biology Lab strive to identify molecular networks and control points that decide how the heart responds to stress, with the overall objective of rewiring these molecular networks to prevent or reverse heart failure. Saucerman has used computation both to build virtual models of how these networks work and to screen thousands of compounds for those that might stimulate heart tissue to regenerate. “Computation is giving us a variety of starting points to attack this problem,†Saucerman said.