Bio
B.S. in Engineering Science, Pennsylvania State University, 2000Ph.D. in Bioengineering, University of California San Diego, 2005"We are mapping the complex networks that control heart function and failure."
Jeffrey Saucerman, Professor of Biomedical Engineering
Our lab combines computational modeling and high-throughput experiments to discover molecular networks and drugs that control cardiac remodeling and regeneration. Our experimental approaches include high-throughput microscopy and -omic profiling of primary and induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Our computational approaches include large-scale regulatory network modeling and bioinformatic analysis of -omic data. Specific focus areas include:
- cardiomyocyte hypertrophy and death
- extra-cellular matrix remodeling by fibroblasts and macrophages
- cardiomyocyte proliferation