Box 800759 Health System Charlottesville, Virginia 22908
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Kevin Janes designs and uses new experimental and computational approaches for analyzing cell signaling and transcriptional networks in cancer and infectious disease. He received his B.S. and B.A. degrees in Biomedical Engineering and Spanish at Johns Hopkins University in 1999. He was a Fulbright Scholar at La Universidad de Santiago de Compostela in Spain before attaining his Ph.D. in Bioengineering at M.I.T. in 2005 under the joint supervision of Douglas Lauffenburger and Michael Yaffe.

Dr. Janes completed a postdoctoral fellowship at Harvard Medical School in the Department of Cell Biology with Joan Brugge and began his faculty position at the University of Virginia in 2008. During that time, Dr. Janes was recognized as a Pew Scholar, a Packard Fellow, a Kavli Fellow, and a recipient of the NIH Director’s New Innovator Award. He is currently an Associate Professor in the Department of Biomedical Engineering at the University of Virginia, the Chair of the Tumor Biochemistry and Endocrinology study section at the American Cancer Society, and a member of the Board of Reviewing Editors for Science Signaling.


B.S. ​Johns Hopkins University, 1999

Ph.D. Massachusetts Institute of Technology, 2005​

Post-Doc ​Harvard Medical School, 2005-2008

"My research combines engineering principles with molecular biology to tackle fundamental problems in cancer and infectious disease."

Kevin Janes Professor

Research Interests

Biomedical Data Sciences
Computational Systems Biology
Quantitative Biosciences

Selected Publications

Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state. Nat Commun, 14, 2110. WANG L*, PAUDEL BB*, MCKNIGHT RA, JANES KA. (2023)
Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback. Cell Syst, 12, 304-23.e1-e13.
Pan-cancer drivers are recurrent transcriptional regulatory heterogeneities in early-stage luminal breast cancer. Cancer Res, 81, 1840-52. SINGH S, SUTCLIFFE MD, REPICH K, ATKINS KA, HARVEY JA, JANES KA. (2021)
Fragmentation of small-cell lung cancer regulatory states in heterotypic microenvironments. Cancer Res, 81, 1853-67. SCHAFF DL*, SINGH S*, KIM K-B, SUTCLIFFE MD, PARK K-S, JANES KA. (2021)
Premalignant oligodendrocyte precursor cells stall in a heterogeneous state of replication stress prior to gliomagenesis. Cancer Res, 81, 1868-82. SUTCLIFFE MD, GALVAO RP, WANG L, KIM J, SINGH S, ZONG H†, JANES KA†. (2021)

Courses Taught

BME 4370/7370 Quantitative Biological Reasoning


Elected to the College of Fellows of the American Institute for Medical and Biological Engineering 2020