Bio

B.A. Chemistry, Rice University, 1981​Ph.D. Chemical Engineering, Rice University, 1989

"We are developing diagnostic tools for blood clotting disorders associated with cardiovascular disease, diabetes, sepsis, and cancer."

Michael B. Lawrence, Associate Professor of Biomedical Engineering

We are interested in the development and clinical translation of diagnostic tools for blood clotting disorders associated with cardiovascular disease, diabetes, chronic liver cirrhosis, sepsis, and cancer. We are applying microfluidic systems integrated with optical and acoustic force probes to define fundamental regulatory mechanisms underlying hemostasis and thrombosis. We are also developing computational approaches to identifying how the immune system and the coagulation system contribute to the progression of multifactorial diseases such as diabetes and atherosclerosis.

Research Interests

  • Biomechanics/Injury Biomechanics or Biomechanics and Mechanobiology
  • Biotechnology and Biomolecular Engineering (Biomolecular Design, Cellular and Molecular Bioengineering)
  • Cardiovascular Engineering

Selected Publications

  • Integration of acoustic radiation force and optical imaging for blood plasma clot stiffness measurement. PloS one. 2015;10(6): e0128799. PMID: 26042775 |PMCID: PMC4456080 ABS Wang C, Perez M, Helmke B, Viola F, Lawrence M.
  • Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease. Journal of controlled release : Controlled Release Society. 2012. ABS Tlaxca J, Rychak J, Ernst P, Konkalmatt P, Shevchenko T, Pizarro T, Pizzaro T, Rivera-Nieves J, Klibanov A, Lawrence M.
  • Adaptive force sonorheometry for assessment of whole blood coagulation. Clinica chimica acta; international journal of clinical chemistry. 2010;411(9): 638-44. ABS Mauldin F, Viola F, Hamer T, Ahmed E, Crawford S, Haverstick D, Lawrence M, Walker W.
  • Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin. PLoS computational biology. 2009;5(2): e1000294. ABS Bailey A, Lawrence M, Shang H, Katz A, Peirce S.
  • L-selectin shear thresholding modulates leukocyte secondary capture. Annals of biomedical engineering. 2008;36(4): 622-31. ABS Paschall C, Lawrence M.
  • Catch strip assay for the relative assessment of two-dimensional protein association kinetics. Analytical chemistry. 2008;80(4): 944-50. ABS Schmidt B, Huang P, Breuer K, Lawrence M.
  • Enhancement of L-selectin, but not P-selectin, bond formation frequency by convective flow. Biophysical journal. 2007;94(3): 1034-45. ABS Paschall C, Guilford W, Lawrence M.
  • Microparticle adhesive dynamics and rolling mediated by selectin-specific antibodies under flow. Biotechnology and bioengineering. 2006;96(3): 596-607. ABS Ham A, Goetz D, Klibanov A, Lawrence M.
  • Neutrophil string formation: hydrodynamic thresholding and cellular deformation during cell collisions. Biophysical journal. 2004;86(6): 4030-9. ABS Kadash K, Lawrence M, Diamond S.
  • The molecular mechanics of P- and L-selectin lectin domains binding to PSGL-1. Biophysical journal. 2003;86(1): 544-54 ABS Rinko L, Lawrence M, Guilford W.

Courses Taught

  • ENGR 1620 Intro to Engineering
  • BME 3240 Biotransport
  • BME 4414 Biomaterials
  • BME 4550 Exogenous Biomaterials

Featured Grants & Projects

  • Thrombosis Systems Bioengineering

    Blood Coagulation Mechanics and Platelet Function


    Our core interest is in the mechanobiology of the blood platelet during thrombosis, the pathological process of blood clotting that can lead to stroke, myocardial infarction, or deep vein thrombosis. Platelets are important regulators of blood clot formation through two mechanisms. One, platelets catalyze thrombin generation to form the fibrin polymer network that creates the blood clot structure. Second, platelets play a key role in fibrin bundling through their IIBIIIA integrins that amplify overall clot strength. To understand how platelets regulate blood coagulation we've developed a novel technology based on acoustic radiation force called sonorheometry that quantifies blood clot viscoelastic properties. With this tool we can track the evolution of the clot's fibrin protein network and platelet modulation of its stiffness via integrin interactions in real-time. Platelet function is therefore assessed in its natural 3-D environment, the blood clot, allowing interrogation of relevant signaling pathways that ultimately regulate blood clot mechanical properties. Platelet regulation of blood clot mechanical properties is critical for successful hemostasis and the avoidance of life-threatening thrombosis. Sonorheometry assessment of blood clot viscoelasticity also permits clinically relevant assessments of the ability of a patient's platelets to stem bleeding. Real-time sonorheometry measures of the effectiveness of a patient's coagulation system can potentially be used to diagnose blood clotting disorders and guide treatment during complex cardiac and neurological surgeries.