B.S. in Physics, University of Rochester, 1988M.S. in Engineering Physics, University of Virginia, 1990Ph.D. in Biomedical Engineering, University of Virginia, 1993Post-Doc in Radiology, University of Virginia, 1994
"Our lab develops new MRI methods for imaging the heart. Some of our methods are used world-wide for clinical imaging or research studies."
Frederick H. Epstein, Mac Wade Professor of Biomedical Engineering
Dr. Epstein is recognized for his contributions to the field of cardiac magnetic resonance imaging (MRI). Dr. Epstein has been a world leader in advancing MRI myocardial strain imaging by developing and applying the cine DENSE (displacement encoding using stimulated echoes) MRI method. He has also made important contributions to accelerated MRI methods and to methods and applications of preclinical MRI in mouse models of heart disease.
Dr. Epstein has chaired the Science Committee of the Society for Cardiovascular MRI (SCMR) (2008) and the ISMRM Cardiac Study Group (2009). He served as an ad hoc member of the NIH NIBIB Board of Scientific Counselors in 2012 and as an international reviewer for the South African Medical Research Council 5-year review of the University of Cape Town Medical Imaging Research Unit (2010). He was recently a member of the Board of Trustees for the SCMR (2013-2015), and he recently served as a standing member of the NIH Study Section Biomedical Imaging Technology A (2012-2016). He is currently a Deputy Editor for Magnetic Resonance in Medicine (2011 – present, the leading technical journal devoted to MRI physics and engineering), and is a member of the American Heart Association Mid-Atlantic Affiliate Research Committee (2014-2017).
Dr. Epstein was the only biomedical engineer invited to speak at the American College of Cardiology Think Tank on the future of cardiac imaging in Washington, DC in 2015. Dr. Epstein is also presently the elected Chair of the American Institute for Biological and Medical Engineering (AIMBE) Academic Council, a group comprised of all BME Department Chairs across the nation. For contributions to research and service, Dr. Epstein is an elected Fellow of three major societies, namely the ISMRM (2013), the American Institute for Biological and Medical Engineering (2014), and the American Heart Association (2014).
Fellow and Established Investigator Award of the American Heart Association (AHA)
Fellow of the International Society for Magnetic Resonance in Medicine (ISMRM)
Fellow of the American Institute for Medical and Biological Engineering (AIMBE)
Epstein Lab post doc Daniel Auger out competed six others to win the Young Investigator Award at the ISMRM 2017 Annual Scientific Meeting. He was the W. S. Moore Award Winner for "Imaging Left-ventricular Mechanical Activation in Heart Failure Patients using Cine DENSE MRI: Validation and Implications for Cardiac Resynchronization Therapy." Listen to his talk here, at about 1:02:36... http://www.ismrm.org/17/program_files/O88.htm.
The Society for Cardiovascular Magnetic Resonance (SCMR) gives just three Early Career Awards each year, and BME graduate student Sophia Cui (Fred Epstein's lab) just won for the Basic Science Division for 2017! Her talk won out against 6 other researchers, including four who already have their PhD or MD degree.
Epstein Lab's Xiaoying Cai is one of seven Fellows by the American Heart Association and the Children’s Heart Foundation for a joint funding venture in congenital heart defect research. Cai works in Dr. Fred Epstein’s lab and was the only predoctoral fellow selected; the other six awardees have already earned their MDs or PhDs.
Myocardial Tissue Tracking with Two-dimensional Cine Displacement-encoded MR Imaging: Development and Initial Evaluation. Radiology 2004:230:862-871. Kim D, Gilson WD, Kramer CM, Epstein FH.
Tracking Myocardial Motion from Cine-DENSE Images using Spatiotemporal Phase Unwrapping and Temporal Fitting. IEEE Trans Med Imag. 2007;26(1):15-30. Spottiswoode BS, Zhong X, Meintjes EM, Mayosi BM, Kramer CM, Epstein FH.
Impact of Mechanical Activation, Scar, and Electrical Timing on Cardiac Resynchronization Therapy: Response and Clinical Outcomes. J Am Coll Cardiol 2014;63(16):1657-1666. Bilchick KC, Kuruvilla S, Hamirani Y, Ramachandran R, Clarke S, Parker KM, Moorman JR, Malhotra R, Mangrum JM, Darby AE, DiMarco J, Holmes JW, Salerno M, Kramer CM, Epstein FH.
Motion‐compensated compressed sensing for dynamic contrast‐enhanced MRI using regional spatiotemporal sparsity and region tracking: Block low‐rank sparsity with motion‐guidance (BLOSM). Magnetic Resonance in Medicine, 72(4), 1028-1038. 2014. Chen, X., Salerno, M., Yang, Y., & Epstein, F. H.
Multi-parameter in vivo Cardiac Magnetic Resonance Imaging Demonstrates Normal Perfusion Reserve Despite Severely Attenuated Beta-adrenergic Functional Response in Neuronal Nitric Oxide Synthase Knockout Mice. European Heart Journal. 2007; 28:2778-2784. Vandsburger MH, French BA, Helm PA, Roy RJ, Kramer CM, Young AA, Epstein FH.
Molecular MRI of Post-Infarct Myocardial Scar in Mice Using a Collagen-Targeting Contrast Agent. Radiology. 2008;247:788-796. Helm PA, Caravan P, French BA, Jacques V, Shen L, Beyers R, Roy RJ, Kramer CM, Epstein FH.