Fibrosis
The deposition of extracellular matrix (ECM) and formation of scar tissue are critical processes in development and the response to injury. Yet excessive ECM deposition can also disrupt function of the heart, lungs, liver, and other organs. Our faculty are using computational modeling, systems biology, imaging, biomaterials development, and tissue engineering to understand, image, and treat fibrosis.
BME Primary Faculty in this Area
Daniel Abebayehu
George Joseph Christ
George Joseph Christ, Ph.D., develops basic and translational tissue engineering and regenerative medicine approaches to organ and tissue repair, reconstruction and replacement, with a focus on the musculoskeletal system, vasculature and lower urinary tract. Dr. Christ is an internationally recognized expert in muscle physiology.
Frederick H. Epstein
Dr. Epstein is recognized for his contributions to the field of cardiac magnetic resonance imaging. He has been a world leader in advancing MRI myocardial strain imaging by developing and applying the cine DENSE (displacement encoding using stimulated echoes) MRI method.
Donald Richieri Griffin
Donald Griffin improves clinical translation of acellular and cellular therapies through enhanced hydrogel-tissue integration, specifically focusing on the development of passive and active instructional microenvironments using microscale building blocks.
Jeffrey Saucerman
Jeffrey Saucerman, PhD, Professor of Biomedical Engineering, combines computational models and high-throughput experiments to discover molecular networks that control cardiac remodeling and regeneration.
More about Fibrosis Research at UVA
UVA Fibrosis Initiative
Mobilizing the University to Fight a Common Killer
A Grounds-wide effort led by TOM BARKER to mobilize UVA researchers conducting fibrosis-related studies. The goal is to produce fundamental insights and facilitate multi-investigator research awards.